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Studies on respiratory infection: I. The influence of particle size on respiratory infection with anthrax spores

Published online by Cambridge University Press:  15 May 2009

H. A. Druett ,
D. W. Henderson ,
L. Packman  and
S. Peacock
H. A. Druett
Affiliation:
Microbiological Research Department, Ministry of Supply, Porton, Wilts
D. W. Henderson
Affiliation:
Microbiological Research Department, Ministry of Supply, Porton, Wilts
L. Packman
Affiliation:
Microbiological Research Department, Ministry of Supply, Porton, Wilts
S. Peacock
Affiliation:
Microbiological Research Department, Ministry of Supply, Porton, Wilts
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Experiments to determine the role of particle size in the infectivity of anthrax spores are described. Clouds of homogeneous particles were produced. The mortality-dosage curves for guinea-pigs and monkeys are given for clouds of various particle sizes. Data are given on the effect of time in the concentration-time relationship. The results are compared with those recorded by other workers on the relationship of particle size to respiratory retention.

Infectivity was highest with single-spore clouds, falling off as particle size increased. Reasons are given for attributing this effect to difference in site of deposition of different-sized particles.

Type
Research Article
Information
Journal of Hygiene , Volume 51 , Issue 3 , September 1953 , pp. 359 - 371
Copyright
Copyright © Cambridge University Press 1953

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