Hostname: page-component-78c5997874-mlc7c Total loading time: 0 Render date: 2024-11-19T04:41:16.823Z Has data issue: false hasContentIssue false
  • English
  • Français

Studies of respiratory viruses in personnel at an Antarctic base

Published online by Cambridge University Press:  15 May 2009

M. J. Holmes ,
T. R. Allen ,
A. F. Bradburne  and
E. J. Stott
M. J. Holmes
Affiliation:
British Antarctic Surveycor1corresp
*
T. R. Allen
Affiliation:
British Antarctic Surveycor1corresp
*
A. F. Bradburne
Affiliation:
W.H.O. Laboratory for Respiratory Virus Diseases, Common Cold Unit, Salisbury, Wiltshire
E. J. Stott
Affiliation:
W.H.O. Laboratory for Respiratory Virus Diseases, Common Cold Unit, Salisbury, Wiltshire
Rights & Permissions [Opens in a new window]

Summary

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

Thirteen men wintering on an Antarctic base were isolated from other human contact for 10 months. During this period Coxsackievirus A21 and later influenza A2 virus were administered to some of the men. Serum samples were collected from each of the men at monthly intervals.

Coxsackievirus A21 produced symptoms and apparently spread to uninoculated men. It also appears that repeated re-infections occurred and that the virus persisted in this small community for most of the period of isolation. HI antibody responses in the absence of neutralizing antibody responses seem to be transient.

The vaccine strain of influenza virus induced antibody responses but did not cause symptoms. There was no evidence of spread to uninoculated men.

Antibody titres against influenza C, parainfluenzaviruses 1 and 2 and coronavirus OC43 did not fall significantly during isolation.

An outbreak of respiratory illness occurred at the end of isolation and its origin was traced. No causative agent was detected.

Type
Research Article
Information
Journal of Hygiene , Volume 69 , Issue 2 , June 1971 , pp. 187 - 199
Copyright
Copyright © Cambridge University Press 1971

References

REFERENCES

Abs, O. (1930). Über Epidemien von unspeziflschen Katarrhen der Luftwege auf Svalbard (Spitzbergen). Skrifter om Svalbard og Ishavet No. 32.Google Scholar
Beare, A. S., Bynoe, M. L. & Tyrrell, D. A. J. (1968). Investigation into the attenuation of influenza viruses by serial passage. British Medical Journal iv, 482.CrossRefGoogle Scholar
Buckland, F. E., Bynoe, M. L. & Tyrrell, D. A. J. (1965). Experiments on the spread of colds: II. Studies in volunteers with Coxsackievirus A21. Journal of Hygiene 63, 327.CrossRefGoogle ScholarPubMed
Cameron, A. S. & Moore, B. W. (1968). The epidemiology of respiratory infection in an isolated Antarctic community. Journal of Hygiene 66, 427.CrossRefGoogle Scholar
Chapple, P. J. (1966). A survey of antibodies to adenovirus 8 and coxsackievirus A21 in human sera. Bulletin of the World Health Organization 34, 243.Google Scholar
Fukumi, H., Nishikawa, F., Sonoguchi, T. & Shimizu, T. (1962). Further studies on the epidemiology of Coe virus infection. Japanese Journal of Medical Science and Biology 15, 145.CrossRefGoogle Scholar
Johnson, K. M., Bloom, H. H., Mufson, M. A. & Chanock, R. M. (1962). Acute respiratory disease associated with Coxsackie A21 virus infection. Journal of the American Medical Association 179, 112.CrossRefGoogle ScholarPubMed
Lennette, E. H., Fox, V. L., Schmidt, N. J. & Culver, J. O. (1958). The Coe virus, an apparently new virus recovered from patients with mild respiratory disease. American Journal of Hygiene 68, 272.Google ScholarPubMed
McDonald, J. C., Miller, D. L., Zuckerman, A. J. & Psreira, M. S. (1962). Coe (Coxsackie A21) virus, para-influenza virus and other respiratory virus infections in the R.A.F. (1958–60). Journal of Hygiene 60, 235.CrossRefGoogle Scholar
McDonald, J. C., Zuckerman, A. J., Beare, A. S. & Tyrrell, D. A. J. (1962). Trials of live influenza vaccine in the Royal Air Force. British Medical Journal i, 1036.CrossRefGoogle Scholar
Marcus, S. & Miya, F. (1964). Effect of different routes of challenge of Coxsackie B virus on cold-stressed mice. Arctic Aeromedical Laboratory Technical Documentary Report 64–2.Google Scholar
Marcus, S., Miya, F., Phelps, L. J. & Spencer, L. (1963). Influence of low ambient temperature on resistance of mice to experimental Coxsaekievirus infection. Arctic Aeromedical Laboratory Technical Documentary Report 62–56.Google Scholar
Oei, K. G. & van der Veen, J. (1967). Epidemiological study of Coxsackie A21 virus infections in military recruits. American Journal of Epidemiology 85, 93.CrossRefGoogle ScholarPubMed
Parrott, R. H., Vargasko, A. J., Kim, H. W., Bell, J. A. & Chanock, R. M. (1962). Respiratory disease of viral aetiology: III. Myxoviruses: Parainfluenza. American Journal of Public Health 52, 907.CrossRefGoogle ScholarPubMed
Parsons, R., Bynoe, M. L., Pereira, M. S. & Tyrrell, D. A. J. (1960). Inoculation of human volunteers with strains of Coe virus isolated in Britain. British Medical Journal i, 1776.CrossRefGoogle Scholar
Pasteur, L., Joubert, J. S. & Chamberland, C. (1878). La théorie des germes et ses applications á la médecine et à la chirurgie. Bulletin de l' Académic de Médicine, 2nd Series 7, 432.Google Scholar
Paul, J. H. & Freese, H. L. (1933). An epidemiological and bacteriological study of the ‘common cold’ in an isolated Arctic community (Spitzbergen). American Journal of Hygiene 17, 517.Google Scholar
Smith, C. B., Purcell, R. H., Bellanti, J. A. & Chanock, R. M. (1966). Protective effect of antibody to parainfluenza type 1 virus. New England Journal of Medicine 275, 1145.CrossRefGoogle ScholarPubMed
Spickard, A., Evans, H., Knight, V. & Johnson, K. (1963). Acute respiratory disease in normal volunteers associated with Coxsackie A21 viral infection: III. Response to nasopharyngeal and enteric inoculation. Journal of Clinical Investigation 42, 840.CrossRefGoogle ScholarPubMed
Stott, E. J. & Tyrrell, D. A. J. (1968). Some improved techniques for the study of rhinoviruses using HeLa cells. Archiv für die gesamte Virusforschung 23, 236.CrossRefGoogle Scholar
Tyrrell, D. A. J. (1965). Common Colds and Related Diseases. London, Edward Arnold, p. 13.Google Scholar
Walker, D. C. & Boring, W. D. (1958). Factors influencing host-virus interactions: III. Further studies on the alteration of Coxsackie virus in adult mice by environmental temperature. Journal of Immunology 80, 39.CrossRefGoogle ScholarPubMed