Hostname: page-component-586b7cd67f-dlnhk Total loading time: 0 Render date: 2024-11-22T06:25:32.641Z Has data issue: false hasContentIssue false
  • English
  • Français

Strain specificity of serum antibody to the haemagglutinin of influenza A (H3N2) viruses in children following immunization or natural infection

Published online by Cambridge University Press:  25 March 2010

J. S. Oxford ,
L. R. Haaheim ,
A. Slepushkin ,
J. Werner ,
E. Kuwert  and
G. C. Schild
J. S. Oxford
Affiliation:
Division of Virology, National Institute for Biological Standards and Control, Holly Hill, London NW3 6RB
L. R. Haaheim
Affiliation:
National Institute of Public Health, Oslo, Norway
A. Slepushkin
Affiliation:
Ivanovsky Institute of Virology, U. Gamalei 16, Moscow 123098, U.S.S.R.
J. Werner
Affiliation:
Institute of Medical Virology and Immunology, University of Essen, Essen 1, Germany
E. Kuwert
Affiliation:
Institute of Medical Virology and Immunology, University of Essen, Essen 1, Germany
G. C. Schild
Affiliation:
Division of Virology, National Institute for Biological Standards and Control, Holly Hill, London NW3 6RB
Rights & Permissions [Opens in a new window]

Summary

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

The specificity of serum anti-HA antibody from children immunized or infected with A/Victoria/75 (H3N2) or A/Texas/77 (H3N2) virus was examined using the single radial haemolysis test together with adsorption of antibody with three antigenic variants A/Hong Kong/68 (H3N2), A/Port Chalmers/73 (H3N2) and A/Victoria/75 (H3N2). The majority of young children reacted to vaccination or infection by producing strain-specific (SS) antibody to the homologous virus. A small proportion of children's sera contained cross-reacting (CR) antibodies capable of reacting with the haemagglutinins of all antigenic variants of the subtype including A/HK/1/68. In contrast, most adults reacted immunologically to either vaccination or infection by producing CR antibody, reacting with all variants of the antigenic subtype including the prototype virus A/HK/1/68 (H3N2).

Type
Research Article
Information
Journal of Hygiene , Volume 86 , Issue 1 , February 1981 , pp. 17 - 26
Copyright
Copyright © Cambridge University Press 1981

References

REFERENCES

Couch, R. B., Webster, R. G., Kasel, J. A. & Cate, T. R. (1979). Efficacy of purified influenza subunit vaccines and relation to the major antigenic determinants on the haemagglutinin molecule. Journal of Infectious Diseases 14, 553.Google Scholar
Gerhard, W. (1976). The analysis of the monoclonal immune response to influenza virus. II. The antigenicity of the viral haemagglutinin. Journal of Experimental Medioine 144, 985.Google Scholar
Haaheim, L. R. (1979). Surveillance of the antibody status to current influenza strains in the Norwegian population. Method of serum sampling and evaluation of the A/USSR/77 (H1N1) impact in various age groups in 1978. Annals of the National Institute of Public Health (Oslo) 2 (2), 45.Google Scholar
Haaheim, L. R. & Schild, G. C. (1979). Antibody to the strain-specific and cross-reactive determinants of influenza H3N2 viruses. 1. Preparation of antibodies and in vitro studies. Acta Pathologica Microbiologica Scandinavia sect. B 87, 291.Google Scholar
Haaheim, L. R. & Schild, G. C. (1980). Antibody to the strain-specific and cross-reactive determinants of influenza H3N2 viruses. 2. Antiviral activities of the antibodies in biological systems. Acta Pathologica Microbiologica Scandinavia (in the press).Google Scholar
Hoskins, T. W., Davies, J. R., Smith, A. J., Miller, C. L. & Allchin, A. (1979). Assessment of inactivated influenza A vaccine after three outbreaks of influenza A at Christ's Hospital. Lancet i, 33.Google Scholar
Kasel, J. A., Couch, R. B., Six, H. R. & Knight, V. (1976). Antigenicity of lioensed whole virion and subvirion influenza vaccines in high risk persons. Proceedings of the Society for Experimental Biology and Medicine 15, 742.Google Scholar
Kasel, J. A., Six, H. R., Couch, R. B., Greenberg, S. B. & Cate, T. R. (1979). Variantspecific antihaemagglutinin serum response to type A influenza natural infection and inactivated vaccines in adults. Proceedings of the Society for Experimental Biology and Medicine 161, 519.Google Scholar
Laver, W. G., Downie, J. C. & Webster, R. G. (1974). Studies on antigenic variation in influenza virus. Evidence for multiple antigenic determinants on the haemagglutinin subunits of A/Hong Kong/68 (H3N2) virus and the A/England/72 strains. Virology 59, 230.Google Scholar
Morris, J. A., Kasel, J. A., Saglam, M., Knight, V. & Loda, F. A. (1966). Immunity to influenza as related to antibody levels. New England Journal of Medicine 274, 527.Google Scholar
Oxford, J. S., Schild, G. C., Potter, C. W. & Jennings, R. (1979). The specificity of the anti-haemagglutinin antibody response induced in man by inactivated influenza vaccines and by natural infection. Journal of Hygiene 82, 51.Google Scholar
Potter, C. W., Jennings, R., Nicholson, K., Tyrrell, D. A. J. & Dickinson, K. G. (1977). Immunity to attenuated influenza virus WRL 105 infection induced by heterologous inactivated influenza A virus vaccine. Journal of Hygiene 79, 321.Google Scholar
Potter, C. W. & Oxford, J. S. (1979). Determinants of immunity to influenza infection in man. British Medical Bulletin 35, 69.Google Scholar
Rovnova, Z. I., Kosyakov, P. N., Berezina, O. N., Isayeva, E. I. & Zhdanov, V. M. (1979). Antigenic determinants in influenza virus haemagglutinin. Infection and Immunity 24, 804.Google Scholar
Schild, G. C., Oxford, J. S. & Virelizikr, J. L. (1976). The immune response to influenza:methods of analysis for antibodies and antigens. In The Role of Immunological Factors in Infectious, Allergic and Autoimmune Processes (ed. Beers, R. F. & Bassett, E. C.), p. 481. New York: Raven Press.Google Scholar
Schild, G. C., Smith, J. W. G., Cretescu, L., Newman, R. W. & Wood, J. M. (1977). Strain specificity of antibody to haemagglutinin following inactivated A/PC/73 vaccine in man: evidence for a paradoxical strain specific antibody response. Developments in Biological Standardization 39, 293.Google Scholar
Skehel, J. J. & Schild, G. C. (1971). The polypeptide composition of influenza A viruses. Virology 44, 396.Google Scholar
Smith, J. W. G. (1976). Vaccination strategy. In Influenza: Virus, Vaccines and Strategy (ed. Selby, P.), pp. 271–94. London and New York: Academic Press.Google Scholar
Sparks, J. P. (1979). Influenza vaccination policy. Lancet i, 317.Google Scholar
Virelizier, J. L. (1975). Host defences against influenza viruses: the role of anti-haemagglutinin antibody. Journal of Immunology 115, 434.Google Scholar
Virelizier, J. L., Allison, A. C. & Schild, G. C. (1974). Antibody responses to antigenio determinants of influenza virus haemagglutinin. II. Original antigenic sin: a bone-marrow-derived lymphocyte memory phenomenon modulated by thymus-derived lymphocytes. Journal of Experimental Medicine 140, 1571.CrossRefGoogle Scholar
Webster, R. G. & Laver, W. G. (1980). Determination of the number of non-overlapping antigenic areas on Hong Kong (H3N2) influenza virus haemagglutinin with monoclonal antibodies and the selection of variants with potential epidemiological significance. Virology 104, 139.Google Scholar
Yewdell, J. W., Webster, R. G. & Gerhard, W. V. (1979). Antigenic variation in three distinct determinants of an influenza type A haemagglutinin molecule. Nature, London 279, 246.Google Scholar