Hostname: page-component-cd9895bd7-jkksz Total loading time: 0 Render date: 2024-12-22T16:24:27.488Z Has data issue: false hasContentIssue false
  • English
  • Français

Staphylococcus pyogenes: the antibiotic sensitivity of strains isolated from human carriers

Published online by Cambridge University Press:  15 May 2009

J. C. Gould  and
Elizabeth J. McKillop
J. C. Gould
Affiliation:
Department of Bacteriology, Edinburgh University
Elizabeth J. McKillop
Affiliation:
Department of Bacteriology, Edinburgh University
Rights & Permissions [Opens in a new window]

Extract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

Strains of Staphylococcus pyogenes able to grow in 0·1 unit/ml. of penicillin produced penicillinase and were regarded as resistant. The majority of the remaining strains had the same sensitivity as the standard sensitive staphylococcus.

Five hundred and three strains were isolated from pre-clinical medical students from 1950 to 1953, and 24% were penicillin-resistant. Two per cent were streptomycin-resistant and none were resistant to chloromycetin, aureomycin or terra-mycin. Two hundred and forty-six of the strains were isolated from persistent and intermittent carriers, but only 14% were penicillin-resistant.

Another 183 strains were isolated from persons unattached to hospital, and 14% were resistant to penicillin. Only one strain was streptomycin-resistant; one was chloromycetin-resistant and none were resistant to the other antibiotics.

Among persistent and intermittent carriers, more than 7 times as many penicillin-resistant strains were isolated from those who had had previous penicillin therapy as from those who had not.

It was concluded that the administration of antibiotic increases the number of resistant strains in the community.

Type
Research Article
Information
Journal of Hygiene , Volume 52 , Issue 4 , December 1954 , pp. 486 - 491
Copyright
Copyright © Cambridge University Press 1954

References

Barber, M. (1947). Staphylococcal infection due to penicillin-resistant strains. Brit. med. J., 2, 863.CrossRefGoogle ScholarPubMed
Barber, M. & Rozwadowska-Dowzenko, (1948). Infection by penicillin-resistant staphylococci. Lancet, 2, 641.CrossRefGoogle ScholarPubMed
Barber, M. & Whitehead, J. E. M. (1949). Bacteriophage types in penicillin-resistant staphylococcal infection. Brit. med. J., 2, 565.CrossRefGoogle ScholarPubMed
Blair, J. E., Carr, M. & Buchman, J. (1946). The action of penicillin on staphylococci. J. Immunol. 52, 281.Google Scholar
Bowie, J. H. (1954). The clinical laboratory aspect of antibiotic therapy. Trans. Edinb. obstet. Soc. (Session CVI), p. 1.Google Scholar
Bruynoghe, G. (1951). Sensitivity of staphylococci to penicillin. Rev. Belge. Path. 21, 194.Google Scholar
Clarke, S., Dalgleish, P. G. & Gillespie, W. P. (1952). Hospital cross-infections with staphylococci resistant to several antibiotics. Lancet, 1, 1132.Google Scholar
Elwood, J. S. (1951). The penicillin sensitivity and phage type of staphylococci isolated from hospital patients. J. Hyg., Camb., 49, 263.Google Scholar
Forbes, G. B. (1949). Infection with penicillin-resistant staphylococci in hospital and general practice. Brit. med. J. 2, 569.CrossRefGoogle ScholarPubMed
Gots, J. S. (1945). The detection of penicillinase-producing properties of micro-organisms. Science, 102, 309.CrossRefGoogle Scholar
Gould, J. C. & Bowie, J. H. (1952). The determination of bacterial sensitivity to antibiotics. Edinb. med. J. 59, 179.Google Scholar
Gould, J. C. & McKillop, E. J. (1954). The carriage of Staph. pyogenes var. aureus in the human nose. J. Hyg., Camb., 52, 304.CrossRefGoogle Scholar
Lowbury, E. J. L., Topley, E. & Wood, A. M. (1952). Chemotherapy for Staphylococcus aureus in burns. Lancet, 1, 1036.CrossRefGoogle ScholarPubMed
Martin, T. D. M. & Whitehead, J. E. M. (1949). Carriage of penicillin-resistant Staphylococcus pyogenes in healthy adults. Brit. med. J. 1, 173.CrossRefGoogle ScholarPubMed
Needham, G. M. & Nichols, D. R. (1953). Recent changes in sensitivity of Micrococcus pyogenes to various antibiotic agents. J. lab. clin. Med. 41, 650.Google ScholarPubMed
Nichols, D. R. & Needham, G. M. (1949). Aureomycin in the treatment of penicillin-resistant staphylococcal bacteraemia. Proc. Mayo Clin. 24, 309.Google Scholar
Rountree, P. M. & Thomson, E. F. (1949). Incidence of penicillin-resistant and streptomycin-resistant staphylococci in hospital. Lancet, 2, 501.CrossRefGoogle Scholar
Rountree, P. M., Barbour, R. G. H. & Thomson, F. F. (1951). Incidence of penicillin-resistant and streptomycin-resistant staphylococci in hospital. Lancet, 1, 435.CrossRefGoogle Scholar
Sherris, J. C. & Florey, M. E. (1951). Relation of penicillin sensitivity in staphylococci to clinical manifestations of infection. Lancet, 1, 309.CrossRefGoogle ScholarPubMed
Summers, G. A. C. (1952). Penicillin-resistant staphylococci. Distribution among out-patients. Lancet, 1, 135.Google Scholar
Williams, R. E. O. & Rippon, J. E. (1952). Bacteriophage typing of Staphylococcus aureus. J. Hyg., Camb., 50, 320.CrossRefGoogle ScholarPubMed