Hostname: page-component-586b7cd67f-gb8f7 Total loading time: 0 Render date: 2024-11-25T08:12:14.520Z Has data issue: false hasContentIssue false

Sporadic acute respiratory infections in adults with special reference to adenovirus infections

Published online by Cambridge University Press:  15 May 2009

Sybille Stovin
Affiliation:
Bacteriology Department of the Royal Free Hospital School of Medicine, Royal Free Hospital, Gray's Inn Road, London, W.C. 1
Rights & Permissions [Opens in a new window]

Extract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

Four out of fifty acute respiratory infections occurring in forty-five adult volunteers in a teaching hospital, from October 1956 to July 1957, were associated with infection by a member of the adenovirus group. In three of these adenovirus infections the clinical picture was quite distinct from that of the common cold, but not from other syndromes of unknown aetiology; in the fourth case the clinical picture was not easily distinguishable from the common cold.

It is suggested on the basis of this study that adenovirus vaccines would do little towards reducing sporadic acute respiratory infections in this type of community.

Complement-fixing and neutralizing antibody patterns to adenovirus Types 1–7, 9 and 10 were determined in paired sera from forty-four of the forty-five volunteers.

I wish to thank all the volunteers who took part in this investigation, Mrs Audrey Rae, A.I.M.L.T., for expert technical assistance, Dr Nuala Crowley and Prof. K. R. Hill, Pathology Department, Royal Free Hospital, Dr H. G. Pereira, National Institute for Medical Research, Mill Hill, and Dr F. K. Sanders, M.R.C. Virus Research Unit, London School of Hygiene, for advice and help.

Type
Research Article
Copyright
Copyright © Cambridge University Press 1958

References

Bell, J. A., Rowe, W. P., Engler, J. I., Pabrott, R. H. & Huebner, R. J. (1955). Pharyngo-conjunctival fever: epidemiological studies of a recently recognized disease entity. J. Amer. med. Ass. 157, 1083.CrossRefGoogle Scholar
Earle, W. R. (1943). Production of malignancy in vitro. IV. The mouse fibroblast cultures and changes seen in living cells. J. nat. Cancer Inst. 4, 165.Google Scholar
Ginsberg, H. S., Gold, E., Jordan, W. S. Jr., Katz, S., Badger, G. F. & Dingle, J. H. (1955). Relation of the new respiratory agents to acute respiratory diseases. Amer. J. publ. Hlth, 45, 915.CrossRefGoogle ScholarPubMed
Grayston, T. J., Loosli, C. G., Johnston, P. B., Smith, M. E. & Woolridge, R. L. (1956). Neutralizing and complement fixing antibody response to adenovirus infection. J. Infect. Dis. 99, 182.CrossRefGoogle ScholarPubMed
Huebner, R. J., Rowe, W. P., Ward, T. G., Parrott, R. H. & Bell, J. A. (1954). Adenoidal-pharyngeal-conjunctival agents. A newly recognized group of common viruses of the respiratory tract. New Engl. J. Med. 251, 1077.CrossRefGoogle Scholar
Kendall, E. J. C., Riddle, R. W., Tuok, H. A., Rodan, K. S., Andrews, B. E. & McDonald, J. C. (1957). Pharyngo-conjunctival fever. School outbreaks in England during the summer of 1955 associated with adenovirus types 3, 7, and 14. Brit. med. J. ii, 131.CrossRefGoogle Scholar
Kjellén, L. (1955). Studies on an unidentified group of cytopathic agents. Arch. ges. Virusforsch. 6, 45.CrossRefGoogle Scholar
Roden, A. T., Pereira, H. G. & Chaproniere, D. M. (1956). Infection of volunteers by a virus (A.P.C. type 1) isolated from human adenoid tissue. Lancet ii, 592.CrossRefGoogle Scholar
Rowe, W. P., Hartley, J. W. & Huebner, R. J. (1956). Additional serotypes of the A.P.C. virus group. Proc. Soc. exp. Biol., N. Y., 91, 260.CrossRefGoogle Scholar
Rowe, W. P., Hdebner, R. J., Hartley, J. W., Ward, T. G. & Parrott, R. H. (1955). Studies of the adenoidal-pharyngeal-conjunctival (A.P.C.) group of viruses. Amer. J. Hyg. 61, 197.Google Scholar
Stallones, R. A., Hilleman, M. R., Gauld, R. L. & Warfield, M. S. (1957). Adenovirus (RI-APC-ARD) vaccine for the prevention of acute respiratory illness. J. Amer. med. Ass. 163, 9.CrossRefGoogle Scholar
Stuart-Harris, C. H. (1955). From Bedson, S. P., Downie, A. W., MacCailum, F. O. & Stuart-Harris, C. H. (1955). Virus and Rickettsial Diseases, 2nd ed. Chapter 11, 236. London: Edward Arnold.Google Scholar
Syverton, J. T. & Scherer, W. F. (1954). The application of mammalian cells in continuous culture for assays in virology. Ann. N. Y. Acad. Sci. 58, no. 7, 1056.CrossRefGoogle ScholarPubMed