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The Spermicidal Powers of Chemical Contraceptives. IV. More Pure Substances

Published online by Cambridge University Press:  15 May 2009

John R. Baker
John R. Baker
Affiliation:
University Demonstrator in Zoology, Oxford.
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1. In the list showing all substances yet tested in the order of their spermicidal powers, the first four substances are all quinones.

2. In the dihydroxybenzenes and their derivatives, the para-position of the two hydroxyl groups confers high spermicidal powers.

3. In the trihydroxybenzenes and their derivatives, the para-position of two of the three hydroxyl groups confers high spermicidal powers.

4. The introduction of a methyl group into quinones and into the di- and trihydroxybenzenes in certain positions increases the spermicidal power.

5. In the hydroxybenzaldehydes and their derivatives, the ortho-position of the hydroxyl and aldehyde groups confers high spermicidal powers.

6. Among the substances so far tested which may be found to be of practical use are orbhovanillin and methoxytoluquinone. These are highly spermicidal, sufficiently soluble and stable in solution. It remains to be seen whether they are harmless to the vagina.

Type
Research Article
Information
Journal of Hygiene , Volume 32 , Issue 2 , April 1932 , pp. 171 - 183
Copyright
Copyright © Cambridge University Press 1932

References

REFERENCES

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