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The Spermicidal Powers of Chemical Contraceptives: III. Pessaries

Published online by Cambridge University Press:  15 May 2009

John R. Baker
John R. Baker
Affiliation:
(University Demonstrator in Zoology, Oxford.)
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1. A technique is described for comparing the spermicidal powers of pessaries, using human sperms.

2. Those pessaries which do not contain cocoa-butter are more spermicidal than those that do.

3. Quinine and lactic acid pessaries, in cocoa-butter vehicles, are almost without effect upon sperms.

4. There is more than ten times as much quinine bisulphate in a quinine pessary as suffices to kill all sperms in half an hour, but the cocoa-butter prevents its action in some way which is not at present understood.

5. Semori is the most spermicidal pessary of the nine investigated. Even at one-tenth of the concentration at which it is normally used, it kills every sperm or nearly every sperm in half an hour.

6. Even if the foam-producing substances are omitted, semori remains effective.

7. The minute quinine urea hydrochloride pessary is nearly as effective as semori, but the absence of foam-producing substances in this pessary limits its usefulness.

8. Speton relies for its spermicidal power wholly upon its foam-producing substances. Its supposedly active substance, sodium dichlorylsulphamidbenzoate, is without effect upon sperms.

Type
Research Article
Information
Journal of Hygiene , Volume 31 , Issue 3 , July 1931 , pp. 309 - 320
Copyright
Copyright © Cambridge University Press 1931

References

REFERENCES

Baker, J. R. (1930). The spermicidal powers of chemical contraceptives. I. Introduction, and experiments on guinea-pig sperms. J. Hygiene, 29, 323–9.CrossRefGoogle Scholar
Baker, J. R. (1931). The spermicidal powers of chemical contraceptives. II. Pure substances. J. Hygiene, 31, 189–214.CrossRefGoogle ScholarPubMed