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Specific immunoglobulin responses after varicella and herpes zoster

Published online by Cambridge University Press:  15 May 2009

J. E. Cradock-Watson ,
Margaret K. S. Ridehalgh  and
M. S. Bourne
J. E. Cradock-Watson
Affiliation:
Public Health Laboratory, Withington Hospital, Manchester M20 8LR
Margaret K. S. Ridehalgh
Affiliation:
Public Health Laboratory, Withington Hospital, Manchester M20 8LR
M. S. Bourne
Affiliation:
University of Manchester Student Health Centre
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Summary

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The indirect immunofluorescence technique has been used to titrate the specific immunoglobulins in 200 sera from 64 patients with varicella, and 195 sera from 67 patients with herpes zoster. IgG and IgM antibodies were detected in all patients with varicella, and IgA in 59 (92%). All three classes of antibody appeared 2–5 days after the onset of the rash, increased virtually simultaneously and reached maximum titres during the second and third weeks. IgG then declined slowly, but never became undetectable and was still present in five subjects who were retested after 2–4 years; it was present in 88 out of 100 healthy young adults and probably persists indefinitely after varicella. IgA and 1gM antibodies declined more rapidly and were not detected in specimens taken more than a year after the illness. IgA, however, may possibly persist in some cases since low titres were found in 8 out of 88 young adults who possessed IgG antibody and had presumably had varicella in the past. IgA responses were significantly weaker in children under the age of 6 years than in older children and adults.

Six out of 67 patients with zoster were tested at various times before the onset of the rash: IgG antibody was detected in all. IgG was present in all sera taken after the onset of the rash, increased rapidly after 2–5 days, reached maximum titres during the second and third weeks and then declined slowly. IgA antibody was detected in 66 patients (99%) and IgM in 52 (78%); both types of antibody followed transient courses, as in varicella.

Maximum titres of IgG and complement-fixing antibodies were greater after zoster than after varicella, but the differences were not significant. IgA and IgM titres in young adults with zoster were significantly lower than in older patients, and also lower than in young adults with varicella.

Increases in varicella-zoster antibody in patients with herpes simplex virus infections consisted mainly of IgG, sometimes IgA, but never IgM.

Type
Research Article
Information
Journal of Hygiene , Volume 82 , Issue 2 , April 1979 , pp. 319 - 336
Copyright
Copyright © Cambridge University Press 1979

References

REFERENCES

Allansmith, M., McClellan, B. H., Butterworth, M. & Maloney, J. R. (1968). The development of immunoglobulin levels in man. Journal of Pediatrics 72, 276.CrossRefGoogle ScholarPubMed
Al-Nakib, W., Best, J. M. & Banatvala, J. E. (1975). Rubella-specific serum and nasopharyngeal immunoglobulin responses following naturally acquired and vaccine-induced infection. Lancet i, 182.CrossRefGoogle Scholar
Asano, Y., Nakayama, H., Yazaki, T., Ito, S., Isomura, S. & Takahasi, M. (1977). Protective efficacy of vaccination in children in four episodes of natural varicella and zoster in the ward. Pediatric 59, 8.Google ScholarPubMed
Best, J. M., Banatvala, J. E. & Watson, D. (1969). Serum IgM and IgG responses in postnatally acquired rubella. Lancet ii, 65.CrossRefGoogle Scholar
Boué, A., Nicolas, A. & Montagnon, B. (1971). Reinfection with rubella in pregnant women. Lancet i, 1251.CrossRefGoogle Scholar
Bradstreet, C. M. P. & Taylor, C. E. D. (1962). Technique of complement-fixation test applicable to the diagnosis of virus diseases. Monthly Bulletin of the Ministry of Health and the Public Health Laboratory Service 21, 96.Google Scholar
Brunell, P. A & Casey, H. L. (1964). Crude tissue culture antigen for determination of varicella-zoster complement-fixation antibody. Public Health Reports 79, 839.CrossRefGoogle Scholar
Brunell, P. A, Gershon, A. A., Uduman, S. A. & Steinberg, S. (1975). Varicella-zoster immunoglobulins during varicella, latency, and zoster. Journal of Infectious Diseases 132, 49.CrossRefGoogle ScholarPubMed
Buckley, R. H., Dees, S. C. & O'Fallon, W. M. (1968). Serum immunoglobulins: 1. Levels in normal children and in uncomplicated childhood allergy. Pediatrics 41, 600.CrossRefGoogle Scholar
Caunt, A. E. & Shaw, D. G. (1969). Neutralization tests with varicella-zoster virus. Journal of Hygiene 67, 343.CrossRefGoogle ScholarPubMed
Cradock-Watson, J. E., Bourne, M. S. & Vandervelde, E. M. (1972). IgG, IgA and IgM responses in acute rubella determined by the immunofluorescent technique. Journal of Hygiene 70, 473.CrossRefGoogle ScholarPubMed
Cradock-Watson, J. E., Ridehalgh, M. K. S. & Chantler, S. (1976). Specific immunoglobulins in infants with the congenital rubella syndrome. Journal of Hygiene 76, 109.CrossRefGoogle ScholarPubMed
Fraser, K. B., Shirodaria, P. V. & Stanford, C. F. (1971). Fluorescent staining and human IgM. British Medical Journal iii, 707.CrossRefGoogle Scholar
Furukawa, T. & Plotkin, S. A. (1972). Indirect hemagglutination test for varicella-zoster infection. Infection and Immunity 5, 835.CrossRefGoogle ScholarPubMed
Gerna, G., Achilli, G. & Chambers, R. W. (1977). Determination of neutralizing antibody and IgG antibody to varicella-zoster virus and of IgG antibody to membrane antigens by the immunoperoxidase technique. Journal of Infectious Diseases 135, 975.CrossRefGoogle ScholarPubMed
Gershon, A. A. & Krugman, S. (1975). Seroepidemiologic survey of varicella: value of specific fluorescent antibody test. Pediatrics 56, 1005.CrossRefGoogle ScholarPubMed
Gershon, A. A., Steinberg, S. & Brunell, P. A. (1974). Zoster immune globulin. A further assessment. New England Journal of Medicine 290, 243.CrossRefGoogle ScholarPubMed
Gold, E. & Godek, G. (1965). Complement fixation studies with a varicella-zoster antigen. Journal of Immunology 95, 692.CrossRefGoogle ScholarPubMed
Hope-Simpson, R. E. (1965). The nature of herpes zoster: a long-term study and a new hypothesis. Proceedings of the Royal Society of Medicine 58, 9.CrossRefGoogle Scholar
Horstmann, D. M., Liebhaber, H., Le Bouvier, G. L., Rosenberg, D. A. & Halstead, S. B. (1970). Rubella: reinfection of vaccinated and naturally immune persons exposed in an epidemic. New England Journal of Medicine 283, 771.CrossRefGoogle Scholar
Jacobs, J. P., Jones, C. M. & Baille, J. P. (1970). Characteristics of a human diploid cell designated MRC-5. Nature, London 227, 168.CrossRefGoogle ScholarPubMed
Kapsenberg, J. G. (1965). Possible antigenic relationship between varicella/zoster virus and herpes simplex virus. Archiv für die gesamte Virusforschung 15, 67.CrossRefGoogle Scholar
Krugman, S., Giles, J. P., Friedman, H. & Stone, S. (1965). Studies on immunity to measles. Journal of Pediatrics 66, 471.CrossRefGoogle ScholarPubMed
Leonard, L. L., Schmidt, N. J. & Lennette, E. H. (1970). Demonstration of viral antibody activity in two immunoglobulin G subclasses in patients with varicella-zoster virus infection. Journal of Immunology 104, 23.CrossRefGoogle ScholarPubMed
Macdonald, H., Tobin, J. O'H., Cradock-Watson, J. E., Lomax, J. & Bourne, M. S. (1978). Antibody titres in women six to eight years after the administration of RA27/3 and Cendehill rubella vaccines. Journal of Hygiene 80, 337.CrossRefGoogle ScholarPubMed
Miller, L. H. & Brunell, P. A. (1970). Zoster, reinfection or activation of latent virus? American Journal of Medicine 49, 480.CrossRefGoogle ScholarPubMed
McGregor, R. M. (1957). Herpes zoster, chicken-pox, and cancer in general practice. British Medical Journal i, 84.CrossRefGoogle Scholar
Ogra, P. L., Kerr-Grant, D., Umana, G., Dzierba, J. & Weintraub, D. (1971). Antibody response in serum and nasopharynx after naturally acquired and vaccine-induced infection with rubella virus. New England Journal of Medicine 285, 1333.CrossRefGoogle ScholarPubMed
Ohta-Hatano, R. & Hinuma, Y. (1966). Mercaptoethanol-sensitive neutralizing antibody in natural infection with Coxsackievirus B5. Proceedings of the Society for Experimental Biology and Medicine 122, 725.CrossRefGoogle ScholarPubMed
Palosuo, T. (1972). Varicella and herpes zoster: differences in antibody response revealed by the platelet aggregation technique. Scandinavian Journal of Infectious Diseases 4, 83.CrossRefGoogle ScholarPubMed
Pattison, J. R. & Dane, D. S. (1975). The routine serological investigation of cases and contacts of rubella. Journal of Hygiene 75, 91.CrossRefGoogle ScholarPubMed
Pike, R. (1967). Antibody heterogeneity and serological reactions. Bacteriological Reviews 31, 157.CrossRefGoogle ScholarPubMed
Ross, C. A. C. & McDaid, R. (1972). Specific IgM antibody in serum of patients with herpes zoster infections. British Medical Journal iv, 522.CrossRefGoogle Scholar
Schluederberg, A. (1965). Immune globulins in human viral infections. Nature, London 205, 1232.CrossRefGoogle Scholar
Schluederberg, A. & Karelitz, S. (1965). Suppression of measles 19S antibody formation as evidence of immunity. Journal of the American Medical Association 191, 86.Google ScholarPubMed
Schmidt, N. J. & Lennette, E. H. (1975). Neutralizing antibody responses to varicellazoster virus. Infection and Immunity 12, 606.CrossRefGoogle Scholar
Schmidt, N. J., Lennette, E. H. & Magoffin, R. L. (1969). Immunologic relationship between herpes simplex and varicella-zoster viruses demonstrated by complement-fixation, neutralization and fluorescent antibody tests. Journal of General Virology 4, 321.CrossRefGoogle ScholarPubMed
Schmidt, N. J., Lennette, E. H., Woodie, J. D. & Ho, H. H. (1965). Immunofluorescent staining in the laboratory diagnosis of varicella-zoster virus infections. Journal of Laboratory and Clinical Medicine 66, 403.Google ScholarPubMed
Svedmyr, A. (1965). Varicella virus in HeLa cells. Archiv für die gesamte Virusforschung 17, 496.CrossRefGoogle ScholarPubMed
Svehag, S-E. & Mandel, B. (1964). The formation and properties of poliovirus-neutralizing antibody. II. 19S and 7S antibody formation: differences in antigen dose requirement for sustained synthesis, anamnesis, and sensitivity to X-irradiation. Journal of Experimental Medicine 119, 21.CrossRefGoogle ScholarPubMed
Taylor-Robinson, D. & Downie, A. W. (1959). Chickenpox and herpes zoster. I. Complement fixation studies. British Journal of Experimental Pathology 40, 398.Google ScholarPubMed
Taylor-Robinson, D. & Rondle, C. J. M. (1959). Chickenpox and herpes zoster. II. Ouchterlony precipitation studies. British Journal of Experimental Pathology 40, 517.Google ScholarPubMed
Weller, T. H. & Coons, A. H. (1954). Fluorescent antibody studies with agents of varicella and herpes zoster propagated in vitro. Proceedings of the Society for Experimental Biology and Medicine 86, 789.CrossRefGoogle ScholarPubMed
Weller, T. H. & Witton, H. M. (1958). Etiologic agents of varicella and herpes zoster: serologic studies with viruses as propagated in vitro. Journal of Experimental Medicine 108, 869.CrossRefGoogle ScholarPubMed
Williams, V., Gershon, A. A. & Brunell, P. A. (1974). Serologic response to varicellazoster membrane antigens measured by indirect immunofluorescence. Journal of Infectious Diseases 130, 669.CrossRefGoogle Scholar