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Specific and non-specific serological markers in the screening for congenital CMV infection

Published online by Cambridge University Press:  15 May 2009

A. El-Mekki ,
L. V. Deverajan ,
S. Soufi ,
O. Strannegard  and
W. Al-Nakib
A. El-Mekki
Affiliation:
From the Departments of MicrobiologyUniversity of Kuwait. P.O. Box 24923, Safat 13110., Kuwait
L. V. Deverajan
Affiliation:
Paediatrics, Faculty of Medicine. University of Kuwait. P.O. Box 24923, Safat 13110., Kuwait
S. Soufi
Affiliation:
From the Departments of MicrobiologyUniversity of Kuwait. P.O. Box 24923, Safat 13110., Kuwait
O. Strannegard
Affiliation:
From the Departments of MicrobiologyUniversity of Kuwait. P.O. Box 24923, Safat 13110., Kuwait
W. Al-Nakib
Affiliation:
From the Departments of MicrobiologyUniversity of Kuwait. P.O. Box 24923, Safat 13110., Kuwait
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Summary

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IgM antibodies specific for cytomegalovirus (CMV) were demonstrated in 15 (2.6%) of 575 umbilical cord sera obtained from newborns in Kuwait. Some 93% and 50% of these CMV-IgM positive cord sera displayed markedly raised (more than normal mean + 2 S.D.) content of total IgM and IgA respectively. In contrast, only 0.2 and 1.8% of the CMV-IgM negative cord sera had elevated total IgM and IgA. respectively. Rheumatoid factor (RF) was demonstrable. at concentrations of 30 IU/ml or more, in 67% of the CMV-IgM positive as compared with 3.2% of the CMV-IgM negative sera whereas interferon alpha was found in the serum of only one of these infants. These results indicate that raised total immunoglobulin. in particular IgM. concentrations and the detection of RF in cord blood are useful non-specific markers for the identification of congenital CMV infection.

Type
Research Article
Information
Epidemiology & Infection , Volume 101 , Issue 3 , December 1988 , pp. 495 - 501
Copyright
Copyright © Cambridge University Press 1988

References

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