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Some Observations on the Immunity and Disability Caused by Vaccinia

Published online by Cambridge University Press:  15 May 2009

Sheldon F. Dudley  and
Percival M. May
Sheldon F. Dudley
Affiliation:
Surgeon Captain, R.N., Royal Naval Medical School
Percival M. May
Affiliation:
Surgeon Captain, R.N. (Retd.), Greenwich Hospital School.
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1. In a group of boys, revaccinated 12 years after primary vaccination in infancy, 37 per cent, gave “immune” reactions to vaccine virus.

2. Immune reactions were more than twice as common in those boys with two or more old vaccination scars than those with one.

3. When the number of scars was held constant there was no tendency for groups with large scars to be more immune than those with small scars.

4. The average area of a single old scar was smaller in the “immunes” than in the rest of the group.

5. The substitution of a vaccination technique consisting of one insertion of lymph with a minimum of trauma, for two or three insertions by “crosshatched” scarifications was followed by nearly a threefold fall in the recorded vaccinia morbidity, and a halving of the number of days' sickness attributed to vaccinia.

Type
Research Article
Information
Journal of Hygiene , Volume 32 , Issue 1 , January 1932 , pp. 25 - 32
Copyright
Copyright © Cambridge University Press 1932

References

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