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Some effects of chloramphenicol in the gut

Published online by Cambridge University Press:  15 May 2009

J. D. Gray
J. D. Gray
Affiliation:
The Pathological Department, Belgrave Hospital for Children, London, S.W.9
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A method for the estimation of chloramphenicol in faeces and bile is described. It has been shown that the bile contains high concentrations of the antibiotic, but the faeces small amounts. It is considered that the faecal concentration is dependent on the biliary supply.

The action of chloramphenicol on the gut flora is described and the dominance of yeasts on complete suppression of the conforms is reported, drawing attention to the possibility of intestinal moniliasis following unrestricted use of the antibiotic.

An explanation of ‘relapses’ in the chloramphenicol treatment of typhoid fever is given, and the possible effect of chloramphenicol on immunity response is discussed.

Type
Research Article
Information
Journal of Hygiene , Volume 51 , Issue 3 , September 1953 , pp. 322 - 329
Copyright
Copyright © Cambridge University Press 1953

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