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Social and geographical risk factors in Helicobacter pylori infection

Published online by Cambridge University Press:  15 May 2009

C. J. Whitaker ,
A. J. Dubiel  and
O. P. Galpin
C. J. Whitaker
Affiliation:
Centre for Applied Statistics, School of Mathematics, University College of North Wales, Dean Street, Bangor, Gwynedd, N. Wales LL57 1UT
A. J. Dubiel
Affiliation:
Centre for Applied Statistics, School of Mathematics, University College of North Wales, Dean Street, Bangor, Gwynedd, N. Wales LL57 1UT
O. P. Galpin
Affiliation:
Centre for Applied Statistics, School of Mathematics, University College of North Wales, Dean Street, Bangor, Gwynedd, N. Wales LL57 1UT
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Summary

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A correlation between childhood crowding and the later development of gastric cancer has been demonstrated by Barker and colleagues, who proposed that the relationship was the consequence of infection by an organism such as Helicobacter pylori. In order to test this hypothesis the presence of IgG antibodies to H. pylori in sera from blood donors in North Wales has been investigated. During donation sessions, donors answered questions relating to social conditions and domicile in childhood (at age 10 years) and adult life (the preceding 2 years).

A stepwise logistic regression analysis of the data demonstrated significant independent relationships between seropositivity and the following factors: sharing a bed in childhood, housing density, locality of birth, adult social class and age.

Type
Research Article
Information
Epidemiology & Infection , Volume 111 , Issue 1 , August 1993 , pp. 63 - 70
Copyright
Copyright © Cambridge University Press 1993

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