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Smoking and polymorphisms of fucosyltransferase gene Le affect success of H. pylori eradication with lansoprazole, amoxicillin, and clarithromycin

Published online by Cambridge University Press:  29 April 2003

K. MATSUO ,
N. HAMAJIMA ,
Y. IKEHARA ,
T. SUZUKI ,
T. NAKAMURA ,
A. MATSUURA ,
K. TAJIMA  and
S. TOMINAGA
K. MATSUO
Affiliation:
Division of Epidemiology and Prevention, Nagoya, Japan Nagoya University Graduate School of Medicine, Nagoya, Japan
N. HAMAJIMA
Affiliation:
Division of Epidemiology and Prevention, Nagoya, Japan
Y. IKEHARA
Affiliation:
Division of Oncological Pathology, Nagoya, Japan
T. SUZUKI
Affiliation:
Department of Gastroenterology, Nagoya University, Japan
T. NAKAMURA
Affiliation:
Department of Gastroenterology, Nagoya University, Japan
A. MATSUURA
Affiliation:
Department of Gastroenterology, Nagoya University, Japan
K. TAJIMA
Affiliation:
Division of Epidemiology and Prevention, Nagoya, Japan
S. TOMINAGA
Affiliation:
Aichi Cancer Center, Nagoya, Japan
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Abstract

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Identification of factors influencing success of Helicobacter pylori (HP) eradication is important for clinical practice. We have prospectively conducted an HP eradication study in the Aichi Cancer Center with a total of 142 patients available for analysis. The overall success rate was 61·3% (95% confidence interval 52·7–69·3%). Smoking during the medication for eradication significantly decreased the success rate (42·9%), whereas smoking cessation during the treatment was associated with a similar rate as for non-smokers (66·7%). We also examined links between an eradication outcome and polymorphisms of Le, Se, IL1A, IL1B, IL1RN and MPO genes, but with one exception none showed any association. The non-functional le allele of Le polymorphisms, leading to decreased expression of Leb antigen to which HP attaches with adhesin, showed a beneficial effect for success. Although further clarification is necessary, our study indicated that smoking cessation and Le gene polymorphisms may affect the success rate of HP eradication.

Type
Research Article
Information
Epidemiology & Infection , Volume 130 , Issue 2 , April 2003 , pp. 227 - 233
Copyright
© 2003 Cambridge University Press