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Signs and symptoms in common colds

Published online by Cambridge University Press:  15 May 2009

D. A. J. Tyrrell ,
S. Cohen  and
J. E. Schilarb
D. A. J. Tyrrell
Affiliation:
MRC Common Cold Unit, Harvard Hospital, Coombe Road, Sailsbury, Wilts, SP2 8BW, UK
S. Cohen
Affiliation:
Department of Psychology, Carnegie Mellon University, Pittsburgh, Pennsylvania 15213, USA
J. E. Schilarb
Affiliation:
Department of Psychology, Carnegie Mellon University, Pittsburgh, Pennsylvania 15213, USA
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Summary

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The patterns of disease caused by five common viruses which infect the respiratory tract are described. The viruses were strains of rhinovirus types 2, 9, and 14, a strain of coronavirus type 229E and of respiratory syncytial virus. Volunteers were given nasal drops containing a low infections dose of one of the viruses, quarantined from 2 days before to 5 days after inoculation, and examined daily by a clinician using a standard checklist of respiratory signs and symptoms. Only subjects who developed clinical illness accompanied by viral shedding and/or specific antibody production were analysed [n = 116]. The results confirm indication from earlier studies that the main difference between colds induced by different viruses is in duration of the incubation period. Patterens of symptom development were not substantially different with different viruses. Analyses of signs and symptoms in different categories, e.g. nasal symptoms v. coughing, justify treatment with different drugs either successively or simultaneously.

Type
Research Article
Information
Epidemiology & Infection , Volume 111 , Issue 1 , August 1993 , pp. 143 - 156
Copyright
Copyright © Cambridge University Press 1993

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