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Shigella species from Addis Ababa: frequency of isolation and in vitro drug sensitivity

Published online by Cambridge University Press:  25 March 2010

Messele Gedebou  and
Alebachew Tassew
Messele Gedebou
Affiliation:
Department of Medical Microbiology and Parasitology, Faculty of Medicine, Addis Ababa University, P.O. Box 1176, Addis Ababa, Ethiopia
Alebachew Tassew
Affiliation:
Department of Medical Microbiology and Parasitology, Faculty of Medicine, Addis Ababa University, P.O. Box 1176, Addis Ababa, Ethiopia
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Summary

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One hundred and five shigella isolates from Addis Ababa were studied to determine serogroup frequency and in vitro antibacterial drug sensitivity.

About 70 % of the isolates were Shigella Flexneri followed by Sh. dysenteriae (15%), Sh. boydii (10%) and Sh. sonnei (5%). All or most of the strains were susceptible to cephalothin, gentamicin, kanamycin, polymyxin B and trimetho-primsulphamethoxazole. Frequencies of susceptibility to ampicillin, carbenicillin and chloramphenicol were, respectively, 79, 80 and 75%. Only 37, 23 and 58% were susceptible to streptomycin, sulphadiazine and tetracycline, respectively.

Resistance to one or more drugs was detected in 85 % while 72 % were multiply resistant. There were 24 different resistance patterns, varying from resistance to one drug to resistance to seven drugs.

The findings have been compared with reports from other countries. This study and several others cited support the view that trimethoprim-sulphamethoxazole is the best alternative drug for treatment of shigellosis particularly in regions with multiple drug-resistant strains.

Type
Research Article
Information
Journal of Hygiene , Volume 88 , Issue 1 , February 1982 , pp. 47 - 55
Copyright
Copyright © Cambridge University Press 1982

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