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Seroprevalence of leptospirosis in a rural flood prone district of Bangladesh

Published online by Cambridge University Press:  15 May 2009

M. G. Morshed ,
H. Konishi ,
Y. Terada ,
Y. Arimitsu  and
T. Nakazawa
M. G. Morshed
Affiliation:
Department of Microbiology, Yamaguchi University School of Medicine, 1144 Kogushi, Ube, Yamaguchi 755, Japan
H. Konishi*
Affiliation:
Department of Microbiology, Yamaguchi University School of Medicine, 1144 Kogushi, Ube, Yamaguchi 755, Japan
Y. Terada
Affiliation:
Department of Microbiology, Yamaguchi University School of Medicine, 1144 Kogushi, Ube, Yamaguchi 755, Japan
Y. Arimitsu
Affiliation:
Department of bacteriology, National Institute of Health, 1-23-1 Toyama, Shinjuku, Tokyo 162, Japan
T. Nakazawa
Affiliation:
Department of Microbiology, Yamaguchi University School of Medicine, 1144 Kogushi, Ube, Yamaguchi 755, Japan
*
* Corresponding author and reprints request to: H. Konishi, Department of Microbiology. Yamaguchi University School of Medicine. 1144 Kogushi. Ube. Yamaguchi 755. Japan.
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Leptospirosis is a worldwide zoonotic disease. In the present investigation, a total of 89 human sera from a flood prone district of Bangladesh was screened by a one-point microscapsule agglutination test (MCAT). MCAT-positive and-doubtful sera were further tested by microscopic agglutination test (MAT) against 16 reference serovars of Leptospira interrogans. and the antibody titres determined. In MCAT, 34 sera were positive and 22 were doubtful. Among those positive and doubtful sera. 33 and 20. respectively were tested by MAT. Thirty-four out of 53 MCAT-screened samples were MAT-positive. The titres ranged from 20 to 1600 with antibodies to serovars copenhageni, australis, cynopteri and icterohaemorrhagiae being the most prevalent. Eleven MCAT-positive samples failed to react with any strains used by MAT, suggesting the presence of new or untested serovars. Among the MAT-positive samples, the presence of antibody against two or more serovars was more common than that of a single serovar. The present study suggests that rural people in Bangladesh are at high risk to leptospiral infection.

Type
Research Article
Information
Epidemiology & Infection , Volume 112 , Issue 3 , June 1994 , pp. 527 - 531
Copyright
Copyright © Cambridge University Press 1994

References

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