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Serological study of the epidemiology of mumps virus infection in north-west England

Published online by Cambridge University Press:  15 May 2009

D. J. Nokes ,
J. Wright ,
P. Morgan-Capner  and
R. M. Anderson
D. J. Nokes
Affiliation:
Parasite Epidemiology Research Group, Department of Biology, Imperial College of Science, Technology and Medicine, Prince Consort Road, London SW7 2BB
J. Wright
Affiliation:
Department of Virology, Royal Preston Hospital, Sharoe Green Lane, Preston PR2 4HG
P. Morgan-Capner
Affiliation:
Department of Virology, Royal Preston Hospital, Sharoe Green Lane, Preston PR2 4HG
R. M. Anderson
Affiliation:
Parasite Epidemiology Research Group, Department of Biology, Imperial College of Science, Technology and Medicine, Prince Consort Road, London SW7 2BB
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Serum samples from individuals of a wide age range, collected in northwest England in 1984 and 1986, provide the basis for an analysis of the epidemiology of mumps virus infection. A radial haemolysis test yielding quantitative antibody measurements was used to screen samples for mumps-specific IgG. Analyses of resultant age-seroprevalence profiles, using statistical models, revealed an age-related pattern in the rate of infection per susceptible similar to that observed for other childhood infections. This rate, or force of infection, was low in young children, high in older children, and low in adults. In addition, the serological surveys provide evidence for time-dependent changes (both epidemic and longer-term) in the rate of mumps virus transmission. The longer-term changes, reflected in the pattern of the age-acquisition of specific antibodies, are supported by evidence from case notification data. The implications of temporal changes in incidence to the interpretation and design of serological surveys are considered.

Type
Special Article
Information
Epidemiology & Infection , Volume 105 , Issue 1 , August 1990 , pp. 175 - 195
Copyright
Copyright © Cambridge University Press 1990

References

REFERENCES

1.Badenoch, J. Big bang for vaccination. Br Med J. 1988; 297: 750.CrossRefGoogle ScholarPubMed
2.Galbraith, NS, Pusey, JJ, Young, SEJ, Crombie, DL, Sparks, JP. Mumps surveillance in England and Wales 1962–81. Lancet 1984; i: 91–4.CrossRefGoogle Scholar
3.Anderson, RM, May, RM. Age-related rates of disease transmission: implications for the design of vaccination programmes. J Hyg 1985; 94: 365–436.CrossRefGoogle Scholar
4.Nokes, DJ, Anderson, RM. The use of mathematical models in the epidemiological study of infectious disease and in the design of mass immunization programmes. Epidemiol Infect 1988; 101: 1–20.CrossRefGoogle ScholarPubMed
5.Mortimer, PP. Mumps prophylaxis in the light of a new test for antibody. Br Med J 1978; ii: 1523–4.CrossRefGoogle Scholar
6.Morgan-Capner, P, Wright, J, Miller, CL, Miller, E. Surveillance of antibody to measles, mumps, and rubella by age. Br Med J 1988; 297: 770–2.CrossRefGoogle ScholarPubMed
7.Anderson, RM, May, RM. Vaccination against rubella and measles: quantitative investigations of different policies. J Hyg 1983; 90: 259–325.CrossRefGoogle ScholarPubMed
8.Anderson, RM, Grenfell, BT. Quantitative investigations of different vaccination policies for the control of congenital rubella syndrome (CRS) in the United Kingdom. J Hyg 1986; 96: 305–33.CrossRefGoogle ScholarPubMed
9.Grenfell, BT, Anderson, RM. The estimation of age-related rates of infection from case notifications and serological data. J Hyg 1985; 95: 419–36.CrossRefGoogle ScholarPubMed
10.Anderson, RM, Crombie, JA, Grenfell, BT. The epidemiology of mumps in the UK: a preliminary study of virus transmission, herd immunity and the potential impact of immunization. J Hyg 1987; 99: 65–84.Google Scholar
11.Cox, MJ, Anderson, RM, Bundy, DAP, Nokes, DJ, Didier, J, Simmons, I, St. Catherine, J. Seroepidemiological study of the transmission of the mumps virus in St Lucia, West Indies. Epidemiol Infect 1989; 102: 147–60.CrossRefGoogle Scholar
12.Nokes, DJ, Anderson, RM, Anderson, MJ. Rubella epidemiology in South East England. J Hyg 1986; 96: 291–304.CrossRefGoogle ScholarPubMed
13.Bailey, NTJ. Statistical methods in biology. 2nd ed.Sevenoaks, Kent: Hodder & Stoughton, 1981.Google Scholar
14.Armitage, P, Berry, G. Statistical methods in medical research. 2nd ed.Oxford: Blackwell Scientific Publications, 1987.Google Scholar
15.Dixon, WJ, ed. BMDP statistical software. 1983 printing with additions. Berkeley: University of California Press, 1983.Google Scholar
16.Neumann, PW, Weber, JM. Single radial hemolysis test for rubella immunity and recent infection. J. Clin Microbiol 1983; 17: 28–34.CrossRefGoogle ScholarPubMed
17.Nokes, DJ. Seroepidemiology of rubella virus in England and the design of control programmes based on mass vaccination. PhD thesis 1987, University of London.Google Scholar
18.Champsaur, H, Dussaix, E, Tournier, P. Haemagglutination inhibition, single radial haemolysis and ELISA tests for the detection of IgG and IgM to rubella virus. J Med Virol 1980; 5: 273–86.3.0.CO;2-J>CrossRefGoogle ScholarPubMed
19.Morgan-Capner, P, Burgess, C, Fisher-Hoch, S. Radial haemolysis for the detection of rubella antibody in acute postnatal rubella. J Hyg 1982; 89: 311–20.CrossRefGoogle ScholarPubMed
20.Bech, V. Titers of complement fixing measles antibodies in human sera collected from one to five years after illness. Acta Path 1960; 50: 81–8.CrossRefGoogle ScholarPubMed
21.O'Shea, S, Best, JM, Banatvala, JE, Shepherd, WM. Development and persistence of class-specific antibodies in the serum and nasopharyngeal washings of rubella vaccinees. J Infect Dis 1985; 151: 89–98.CrossRefGoogle ScholarPubMed
22.Scott, ME. Reproductive potential of Gyrodactylus bullatarudis (Monogenea) on guppies (Poecilia reticulata). Parasitology 1982; 85: 217–36.CrossRefGoogle Scholar
23.Nokes, DJ, McLean, AR, Anderson, RM, Grabowsky, M. Measles immunization strategies for countries with high transmission rates: interim guidelines predicted using a mathematical model. Int J Epidem. (In the Press.)Google Scholar
24.Schenzle, D, Dietz, K, Frosner, GG. Hepatitis A antibody in seven European countries. II. Statistical analysis of cross-sectional surveys. Am J Epidem 1979; 110: 70–6.CrossRefGoogle Scholar
25.Sokal, RR, Rohlf, FT. Biometry. 2nd ed.San Francisco: W.H. Freeman & Company, 1981.Google Scholar
26.Report. Statistics of schools in England, January 1986. Department of Education and Science, Statistical Bulletin 1987. Elizabeth House, London.Google Scholar
27.Nokes, DJ, Anderson, RM. Measles, mumps and rubella vaccine: what coverage to block transmission? Lancet 1988; ii: 1374.CrossRefGoogle Scholar