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Serological studies in a student population prone to infection with human papilloma virus

Published online by Cambridge University Press:  15 May 2009

Heather A. Cubie
Heather A. Cubie
Affiliation:
Department of Bacteriology, University of Edinburgh
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Four hundred and sixty-seven serum specimens from the female students at a residential college were examined for the presence of circulating antibody to human wart virus using the technique of counter-current immunoelectroosmophoresis. A significantly higher incidence of antibodies was found in students with a past history of plantar warts than in any other group. Antibody took several months to develop and was detectable in 20–30 % of the students up to 9 years after infection. From a few cases of multiple infection, it was shown that reinfection could occur in spite of the presence of circulating antibodies probably of the IgG class. The sensitivity of the test was compared with two recognized techniques for detection of wart virus antibodies, namely gel diffusion and passive haemagglutination.

Type
Research Article
Information
Journal of Hygiene , Volume 70 , Issue 4 , December 1972 , pp. 677 - 690
Copyright
Copyright © Cambridge University Press 1972

References

REFERENCES

Allen, W. H. & Dickinson, V. A. (1968). The problem of verrucae–a prevalence survey and a study of certain aetiological factors. Medical Officer 119, 261–4.Google Scholar
Allison, A. C. (1967). Cell mediated immune responses to virus infection and virus-induced tumours. British Medical Bulletin 23, 60–65.CrossRefGoogle ScholarPubMed
Almeida, J. D. & Goffe, A. P. (1965). Antibody to wart virus in human sera detected by electron microscopy and precipitin tests. Lancet ii, 1205–7.CrossRefGoogle Scholar
Alpert, E., Monroe, M. & Schur, P. H. (1970). A method for increasing the sensitivity of radial-immunodiffusion assay. Lancet i, 1120.CrossRefGoogle Scholar
Bunney, M. H. (1971). Plantar warts. Prevention is better than cure. Paper read at British Association of Dermatology meeting, Edinburgh, 15 July 1971.Google Scholar
Bunney, M. H. (1972). The prevention of plantar warts by the use of protective footwear in the swimming pool. Community Medicine 127, 127–9.Google Scholar
Bunney, M. H., Hunter, J. A., Ogilvie, M. M. & Williams, D. A. (1971). The treatment of plantar warts in the home. A critical appraisal of a new preparation. The Practitioner 207, 197–204.Google Scholar
Bussard, A. (1959). Description d'une technique combinant simultanément l'éctrophorèse et la précipitation immunologique dans un gel: l'éctrosynérèse. Biochimica et Biophysica Acta 34, 258–60.CrossRefGoogle Scholar
Das, P. C., Hopkins, R., Cash, J. D. & Cumming, R. A. (1971). Rapid identification of hepatitis associated antigen and antibody by counter-immunoelectroosmophoresis. British Journal of Haematology 21, 673–6.CrossRefGoogle ScholarPubMed
Evans, C. A., Weiser, R. S. & Ito, Y. (1962). Antiviral and antitumour immunologic mechanisms operative in the Shope papilloma-carcinoma system. Cold Spring Harbour Symposium on Quantitative Biology 27, 453–62.CrossRefGoogle Scholar
Goffe, A. P., Almeida, J. A. & Brown, F. (1966). Further information on the antibody response to wart virus. Lancet ii, 607–9.CrossRefGoogle Scholar
Hall, R. & Burrows, D. (1968). Diagnostic review of hospital dermatology in Northern Ireland, 1954–66. British Journal of Dermatology 80, 261–4.CrossRefGoogle ScholarPubMed
Kidd, J. G., Beard, J. W. & Rous, P. (1936). Serological reactions with a virus causing a rabbit papilloma which becomes cancerous. II. Tests of the blood of animals carrying various tumours. Journal of Experimental Medicine 64, 63–78.CrossRefGoogle Scholar
Kreider, J. W. (1963). Studies on the mechanism responsible for the spontaneous regression of the Shope rabbit papilloma. Cancer Research 23, 1593–7.Google ScholarPubMed
Lee, K. P. & Olson, C. (1968). Response of calves to intravenous and repeated intradennal inoculation of bovine papilloma virus. American Journal of Veterinary Research 29, 2103–12.Google ScholarPubMed
Lee, K. P. & Olson, C. (1969). Precipitin response of cattle to bovine papilloma virus. Cancer Research 29, 1393–7.Google ScholarPubMed
Ogilvie, M. M. (1970 a). Serological studies with human papova (wart) virus. Journal of Hygiene 68, 479–90.CrossRefGoogle ScholarPubMed
Ogilvie, M. M. (1970 b). Virological and immunological aspects of infection with the human papova (wart) virus. M.D. Thesis, University of Edinburgh.CrossRefGoogle Scholar
Ouchterlony, Ö. (1964). In Immunological Methods (ed. Ackroyd, J. F.), p. 55. Oxford: Blackwell.Google Scholar
Pesendorfer, F., Krassnitsky, O. & Wewalka, F. (1970). Immunodiffusion and immunoelectrophoretic techniques. Vox Sanguinis 19, 202–4.CrossRefGoogle ScholarPubMed
Prince, A. M. & Burke, K. (1970). Serum hepatitis antigen (S. H.): rapid detection by high voltage immunoelectrophoresis. Science, New York 169, 593–5.CrossRefGoogle Scholar
Rasmussen, K. A. (1958). Verrucae plantares. Symptomatology and epidemiology. Acta Dermato-venereologica (Stockholm) 38, suppl. 39.Google ScholarPubMed
Rowson, E. K. & Mahy, B. W. J. (1967). Human papova (wart) virus. Bacteriological Reviews 31, 110–31.CrossRefGoogle ScholarPubMed
Tranter, A. W. (1969). A scheme for the prevention of plantar warts (an extended study of the incidence of plantar warts in the Borough of Lewisham). Medical Officer 120, 317–22.Google Scholar
Watson, D. H., Russell, W. C. & Wildy, P. (1963). Electron microscopic particle counts on herpes virus using the phosphotungstate negative staining technique. Virology 19, 258–60.CrossRefGoogle ScholarPubMed