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The seroepidemiology of B. pertussis infection in Catalonia, Spain

Published online by Cambridge University Press:  30 May 2001

A. DOMÍNGUEZ ,
J. VIDAL ,
P. PLANS  and
L. SALLERAS
A. DOMÍNGUEZ
Affiliation:
General Directorate of Public Health, Department of Health and Social Security, Autonomous Government of Catalonia, Travessera de les Corts, 131–159, 08028 Barcelona, Spain
J. VIDAL
Affiliation:
Microbiology Unit, Hospital Clínic, C/ Villarroel, 170, 08036 Barcelona, Spain
P. PLANS
Affiliation:
General Directorate of Public Health, Department of Health and Social Security, Autonomous Government of Catalonia, Travessera de les Corts, 131–159, 08028 Barcelona, Spain
L. SALLERAS
Affiliation:
General Directorate of Public Health, Department of Health and Social Security, Autonomous Government of Catalonia, Travessera de les Corts, 131–159, 08028 Barcelona, Spain
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Abstract

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A survey of the seroprevalence of pertussis antibodies in a representative sample of the population from Catalonia was carried out. Ninety-seven municipalities and 30 schools were randomly selected to recruit the 2126 subjects who participated in the study. A serum sample was obtained from all individuals participating in the study in order to determine levels of pertussis toxin (PT) and filamentous hemagglutinin (FHA) antibodies by ELISA test. Sociodemographic data were collected for all subjects. The prevalence of PT antibodies was 75 % and that of FHA antibodies 89 %. Significant increments were observed with age, both in the prevalence of PT (P < 0·0001) and of FHA (P = 0·018). Of the sociodemographic variables studied, only urban habitat was significantly associated to PT antibodies. The agreement observed among the two types of antibodies studied was weak (κ = 0·264). Routine revaccination with the acellular vaccine in children over 7 years of age, in adolescents and adults seems a reasonable strategy to prevent the appearance of cases of pertussis in the community.

Type
Research Article
Information
Epidemiology & Infection , Volume 126 , Issue 2 , April 2001 , pp. 205 - 210
Copyright
© 2001 Cambridge University Press