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Selective elimination of Enterobacteriaceae species from the digestive tract in mice and monkeys

Published online by Cambridge University Press:  15 May 2009

D. van der Waaij  and
J. M. Berghuis-de Vries
D. van der Waaij
Affiliation:
Radiobiological Institute TNO, Lange Kleiweg 151, Rijswijk (Z.H.) The Netherlands
J. M. Berghuis-de Vries
Affiliation:
Radiobiological Institute TNO, Lange Kleiweg 151, Rijswijk (Z.H.) The Netherlands
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Summary

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In mice and in monkeys, ‘selective’ elimination of Enterobacteriaceae species from the digestive tract of animals with a sensitive flora was accomplished by oral treatment with nalidixic acid (1 mg./g. body weight in mice and 0·4 mg./g. body weight in monkeys). During treatment, the concentration of enterococci (and also of Candida albicans in the monkey) remained unaltered. This indicates that the fraction of the anaerobic microflora which is responsible for the colonization resistance of the digestive tract is not affected by the treatment. An important consequence seems to be, that elimination of yeast and fungi with fungistatic drugs can be started at the same time as elimination of Enterobacteriaceae is attempted.

Type
Research Article
Information
Journal of Hygiene , Volume 72 , Issue 2 , April 1974 , pp. 205 - 211
Copyright
Copyright © Cambridge University Press 1974

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