Hostname: page-component-f554764f5-fnl2l Total loading time: 0 Render date: 2025-04-12T15:09:48.705Z Has data issue: false hasContentIssue false
  • English
  • Français

Selective elimination of Enterobacteriaceae species from the digestive tract in mice and monkeys

Published online by Cambridge University Press:  15 May 2009

D. van der Waaij  and
J. M. Berghuis-de Vries
D. van der Waaij
Affiliation:
Radiobiological Institute TNO, Lange Kleiweg 151, Rijswijk (Z.H.) The Netherlands
J. M. Berghuis-de Vries
Affiliation:
Radiobiological Institute TNO, Lange Kleiweg 151, Rijswijk (Z.H.) The Netherlands
Rights & Permissions [Opens in a new window]

Summary

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

In mice and in monkeys, ‘selective’ elimination of Enterobacteriaceae species from the digestive tract of animals with a sensitive flora was accomplished by oral treatment with nalidixic acid (1 mg./g. body weight in mice and 0·4 mg./g. body weight in monkeys). During treatment, the concentration of enterococci (and also of Candida albicans in the monkey) remained unaltered. This indicates that the fraction of the anaerobic microflora which is responsible for the colonization resistance of the digestive tract is not affected by the treatment. An important consequence seems to be, that elimination of yeast and fungi with fungistatic drugs can be started at the same time as elimination of Enterobacteriaceae is attempted.

Type
Research Article
Information
Journal of Hygiene , Volume 72 , Issue 2 , April 1974 , pp. 205 - 211
Copyright
Copyright © Cambridge University Press 1974

References

Abrams, G. D. & Bishop, J. E. (1967). Effect of the normal microbial flora on gastro-intestinal motility. Proceedings of the Society for Experimental Biology and Medicine 126, 301.Google Scholar
Dankert, J. (1973). Biotyping of Enterobacteriaceae: a method to determine the efficacy of the barrier function of isolation units. Proc. IVth Int. Symp. on Germfree Research, New Orleans, 1972. In Germfree Research (ed. Heneghan, J. B.), p. 59.Google Scholar
Sneath, P. H. A. (1956). Cultural and biochemical characteristics of the genus Chromo-bacteriurn. Journal of General Microbiology 15, 70.Google Scholar
Waaij, D. van der (1968). The persistent absence of Enterobacteriaceae from the intestinal flora of mice following antibiotic treatment. Journal of Infectious Diseases 118, 32.CrossRefGoogle ScholarPubMed
Waaij, D. van der, de Vries, J. M. & Lekkerkerk, J. E. C. (1970). Eliminating bacteria from monkeys with antibiotics. In Infections and Immunosuppression in Subhuman Primates (ed. Balner, H. and Beveridge, W. I. B.), Copenhagen: Munksgaard, p. 21.Google Scholar
Waaij, D. van der, Berghuis-de Vries, J. M. & Lekkerkerk-van der Wees, J. E. C. (1971). Colonization resistance of the digestive tract in conventional and antibiotic-treated mice. Journal of Hygiene 69, 405.Google Scholar
Waaij, D. van der, Berghuis, J. M. & Lekkerkerk, J. E. C. (1972). Colonization resistance of the digestive tract of mice during systemic antibiotic treatment. Journal of Hygiene 70, 605.Google Scholar
Wensinck, F. & Ruseler-van Embden, J. G. H. (1971). The intestinal flora of colonization-resistant mice. Journal of Hygiene 69, 413.Google Scholar
Williams, R. C. & Gibbons, R. J. (1972). Inhibition of bacterial adherence by secretory immunoglobulin A: a mechanism of antigen disposal. Science, New York 177, 697.Google Scholar