Hostname: page-component-cd9895bd7-7cvxr Total loading time: 0 Render date: 2024-12-22T15:19:48.240Z Has data issue: false hasContentIssue false
  • English
  • Français

Selective antenatal screening for toxoplasmosis and the latex agglutination test

Published online by Cambridge University Press:  15 May 2009

R. E. Holliman ,
K. F. Barker  and
J. D. Johnson
R. E. Holliman
Affiliation:
Public Health Laboratory Service, Toxoplasma Reference Laboratory, St George's Hospital, Blackshaw Road, London SW17 0QT, UK
K. F. Barker
Affiliation:
Public Health Laboratory Service, Toxoplasma Reference Laboratory, St George's Hospital, Blackshaw Road, London SW17 0QT, UK
J. D. Johnson
Affiliation:
Public Health Laboratory Service, Toxoplasma Reference Laboratory, St George's Hospital, Blackshaw Road, London SW17 0QT, UK
Rights & Permissions [Opens in a new window]

Summary

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

Recent publicity concerning congenital toxoplasmosis has generated a demand for serological assessment of pregnant women. Many laboratories are requested to undertake primary screening in these cases. We assessed the latex agglutination test (LAT) findings in 158 specimens with detectable toxoplasma specific IgM derived from pregnant women. The LAT titres ranged from 16 to ≥ 4000 reflecting the variable antibody response observed in acute toxoplasmosis. We recommend that non-reference laboratories test specimens from pregnant women using the LAT at a screening dilution of 1:16 and select all reactive samples for detailed investigation.

Type
Research Article
Information
Epidemiology & Infection , Volume 105 , Issue 2 , October 1990 , pp. 409 - 414
Copyright
Copyright © Cambridge University Press 1990

References

REFERENCES

1.Joynson, DH, Payne, R. Screening for toxoplasma in pregnancy. Lancet 1988; ii: 795–6.CrossRefGoogle Scholar
2.Ho-Yen, DO. Screening for congenital cytomegalovirus and toxoplasmosis. Lancet 1989; ii: 803.CrossRefGoogle Scholar
3.Burr, ML, Elwood, PC. Research and development of health promotion services-screening. In: Holland, WW, Detels, R, Knox, G, eds. Oxford textbook of public health, vol. 3. Oxford: Oxford University Press, 1985: 373.Google Scholar
4.Joynson, DHM, Payne, RA, Balfour, AH, Prestagne, ES, Fleck, DG, Chessum, BS. Evaluation of five commercial enzyme linked immunosorbent assay kits for toxoplasma specific IgM antibody. J Clin Pathol 1989; 46: 655–7.Google Scholar
5.Wreghitt, TG, Hakim, M, Gray, JJ et al. , Toxoplasmosis in heart and heart and lung transplant recipients. J Clin Pathol 1989; 42: 194–9.CrossRefGoogle ScholarPubMed
6.Aroujo, FG, Remington, JS. Toxoplasmosis in immunocompromised patients. Eur J Clin Microbiol 1987; 6: 1–2.CrossRefGoogle Scholar
7.Johnson, J, Duffy, K, New, L, Holliman, RE, Chessum, BS, Fleck, DG. Direct agglutination test and other assays for measuring antibodies to Toxoplasma gondii. J Clin Pathol 1989; 42: 536–41.CrossRefGoogle ScholarPubMed
8.Duffy, KT, Wharton, PJ, Johnson, JD, New, L, Holliman, RE. Assessment of an immunoglobulin-M immunosorbent agglutination assay (ISAGA) for the detection of toxoplasma specific IgM. J Clin Pathol 1989; 42: 1291–5.CrossRefGoogle ScholarPubMed
9.Holliman, RE, Johnson, J, Duffy, K, New, L. Discrepant toxoplasma latex agglutination test results. J Clin Pathol 1989; 42: 200–3.CrossRefGoogle ScholarPubMed
10.Holliman, RE, Johnson, JD. The post-natal serodiagnosis of congenital toxoplasmosis Serodiag Immunother 1989; 3: 323–7.CrossRefGoogle Scholar
11.Kean, BH. Clinical toxoplasmosis-50 years. Trans Roy Soc Trop Med Hyg 1972; 66: 549–71.CrossRefGoogle ScholarPubMed
12.Koppe, JG, Loewer-Sieger, DH, de Roever-Bonnet, H. Results of 20 year follow-up of congenital toxoplasmosis. Lancet 1986; i: 254–6.CrossRefGoogle Scholar
13.Huskinson, J, Stepick-Biek, PN, Araujo, FG, Thulliez, P, Suzuki, Y, Remington, JS. Toxoplasma antigens recognised by immunoglobulin-G subclasses during acute and chronic infection. J Clin Microbiol 1989; 27: 2031–8.CrossRefGoogle ScholarPubMed
14.Daffos, F, Forestier, F, Capella-Pavlowsky, M et al. , Prenatal management of 746 pregnancies at risk for congenital toxoplasmosis. N Engl J Med 1988; 318: 271–5.CrossRefGoogle ScholarPubMed