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Secretor status and humoral immune responses to Neisseria lactamica and Neisseria meningitidis

Published online by Cambridge University Press:  15 May 2009

A. A. Zorgani ,
J. Stewart ,
C. C. Blackwell ,
R. A. Elton  and
D. M. Weir
A. A. Zorgani
Affiliation:
Departments of Medical Microbiology, Edinburgh, Scotland EH8 9AG
J. Stewart
Affiliation:
Departments of Medical Microbiology, Edinburgh, Scotland EH8 9AG
C. C. Blackwell
Affiliation:
Departments of Medical Microbiology, Edinburgh, Scotland EH8 9AG
R. A. Elton
Affiliation:
Public Health Sciences, The Medical School, University of Edinburgh, Teviot Place, Edinburgh, Scotland EH8 9AG
D. M. Weir
Affiliation:
Departments of Medical Microbiology, Edinburgh, Scotland EH8 9AG
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Summary

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Non-secretors of ABO blood group antigens are over-represented among patients with meningococcal diseases. Lower levels of secretory IgA reported for non-secretors have been suggested to compromise mucosal defences. Total serum and salivary IgG, IgA and IgM and levels of these isotypes specific for Neisseria lactamica and five isolates of meningococci were determined by ELISA for 357 pupils and staff of a secondary school in which an outbreak of meningitis occurred. There were no differences in total or specific levels of serum IgG, IgA or IgM or salivary IgG or IgA of secretors compared with non-secretors. Non-secretors had significantly lower levels of salivary IgM (P=0·022) A similar pattern was observed for levels of IgM specific for N. lactamica and five meningococcal isolates. The significance of these results is discussed with reference to the role of secretory IgM in protection of mucosal surfaces in infants.

Type
Research Article
Information
Epidemiology & Infection , Volume 109 , Issue 3 , December 1992 , pp. 445 - 452
Copyright
Copyright © Cambridge University Press 1992

References

REFERENCES

1.Brandtzaeg, P, Fjellanger, I, Gjeruldsen, S. Human secretory immunoglobulin I. Salivary secretions from individuals with normal or low levels of serum immunoglobulins. Scand J Haemat Suppl 1970; 12: 1–83.Google ScholarPubMed
2.Smith, DJ, King, WF, Taubman, MA. Isotype, subclass and molecular size of immunoglobulins in saliva from young infants. Clin Exp Immunol 1989; 76: 97–102.Google ScholarPubMed
3.Brandtzaeg, P. Transport models for secretory IgA and secretory IgM. Clin Exp Immunol 1981; 44: 221–32.Google ScholarPubMed
4.Haworth, JC, Dilling, L. Concentration of vA globulin in serum, saliva and nasopharyngeal secretions of infants and children. J Clin Lab Med 1966; 67: 922–33.Google Scholar
5.Berg, T. Immunoglobulin levels in infants with low birth weights. Acta Pediat Scand 1968; 57: 369–76.CrossRefGoogle ScholarPubMed
6.Burgio, GR, Lanzavecchia, A, Plebani, A, Jayakar, S, Ugazio, AG. Ontogeny of secretory immunity: Levels of secretory IgA and natural antibodies in saliva. Paediatric Res 1980; 14: 1111–4.CrossRefGoogle ScholarPubMed
7.Mellander, L, Carlsson, B, Hansson, LA. Appearance of secretory IgM and IgA antibodies to Escherichia coli in saliva during early infancy and childhood. J Pediat 1984; 104: 564–8.CrossRefGoogle ScholarPubMed
8.Mellander, L, Carlsson, B, Hanson, LA. Secretory IgA and IgM to E. coli and poliovirus type 1 antigens occur in amniotic fluid, meconium and saliva from newborns. A neonatal immune response without antigenic exposure: a result of idiotypic induction? Clin Exp Immunol 1986; 63: 555–61.Google Scholar
9.Goldschneider, I, Gotschlich, EC, Artenstein, MS. Human immunity to the meningococcus. I. The role of humoral antibody. J Exp Med 1969; 129: 1307–26.CrossRefGoogle Scholar
10.Goldschneider, I, Gotschlich, EC, Artenstein, MS. Human immunity to the meningococcus. II. Development of natural immunity. J Exp Med 1969; 129: 1327–48.CrossRefGoogle Scholar
11.Lee, TJ, Ustanger, PD, Snyderman, R, Young, WJ, Sparling, PF. Familial deficiency of the seventh component of complement associated with recurrent bacteraemic infection due to Neisseria. J Infect Dis 1978; 138: 359–68.CrossRefGoogle Scholar
12.Reller, LB, MacGregor, RR, Beaty, HN. Bactericidal antibody after colonization with Neisseria meningitidis. J Infect Dis 1973; 127: 56–62.CrossRefGoogle ScholarPubMed
13.Blackwell, CC, Jónsdottir, K, Hanson, M, et al. Non-secretion of ABO blood group antigens predisposing to infection by Neisseria meningitidis and Streptococcus pneumoniae. Lancet 1986; ii: 284–5.CrossRefGoogle Scholar
14.Blackwell, CC, Jónsdottir, K, Mohammed, I, Weir, DM. Non-secretion of blood group antigens. A genetic factor predisposing to infection by N. meningitidis. In: Gonococci and meningococci, Poolman, JT, et al., eds. Dordrecht: Kluwer Academic Publishers, 1988; 633–6.CrossRefGoogle Scholar
15.Blackwell, CC, Weir, DM, James, VS, et al. Secretor status, smoking and carriage of Neisseria meningitidis. Epidemiol Infect 1990; 104: 203–9.CrossRefGoogle ScholarPubMed
16.Glynn, AA, Glynn, LE, Holborow, EJ. Secretor status of rheumatic-fever patients. Lancet 1956; ii: 759–62.CrossRefGoogle Scholar
17.Clarke, CA, McConnell, RB, Sheppard, PM. ABO blood groups and secretor character in rheumatic carditis. Br Med J 1960; 1: 21–3.CrossRefGoogle ScholarPubMed
18.Grundbacher, FJ. Immunoglobulins, secretor status and the incidence of rheumatic fever and rheumatic heart disease. Hum Hered 1972; 22: 399–404.CrossRefGoogle ScholarPubMed
19.Waissbluth, JG, Langman, MS. ABO blood groups, secretor status, salivary proteins, serum and salivary immunoglobulin concentrations. Gut 1971; 12: 646–9.CrossRefGoogle Scholar
20.Young, H. Cultural diagnosis of gonorrhoea with Modified New York City (MNYC) medium. Br J Vener Dis 1978; 54: 36–40.Google ScholarPubMed
21.Blackwell, CC, Jónsdottir, K, Weir, DM, et al. Blood group, secretor status and susceptibility to bacterial meningitis. FEMS Microbiol Immunol 1989; 47: 351–6.CrossRefGoogle Scholar
22.Hobbs, JR, Milner, RDG, Watt, PJ. Gamma-M deficiency predisposing to meningococcal septicaemia. Br Med J 1967; 4: 583–6.CrossRefGoogle ScholarPubMed
23.Jones, DM, Tobin, BM, Butterworth, A. Three cases of meningococcal infection in a family, associated with a deficient immune response. Arch Dis Child 1973; 48: 742–3.CrossRefGoogle Scholar
24.Ogra, PL, Coppola, PR, MacGillivray, MH, Dzierba, JL. Mechanism of mucosal immunity to viral infections in A immunoglobulin-deficiency syndrome (37900). Proc Soc Exp Biol Med 1974; 145: 811–6.CrossRefGoogle Scholar
25.Gleeson, M, Cripps, AW, Clancy, RL, Husband, AJ, Hensley, MJ, Leeder, SR. Ontogeny of secretory immune system in man. Aus NZ J Med 1982; 12: 255–8.CrossRefGoogle ScholarPubMed