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Rubella-specific IgM reactivity in sera from cases of infectious mononucleosis

Published online by Cambridge University Press:  15 May 2009

P. Morgan-Capner ,
R. S. Tedder  and
J. E. Mace
P. Morgan-Capner
Affiliation:
Department of Medical Microbiology, King's College Hospital Medical School, London, SE5 8RX
R. S. Tedder
Affiliation:
Department of Virology, Middlesex Hospital Medical School, London, W1P 7PP
J. E. Mace
Affiliation:
Department of Virology, Middlesex Hospital Medical School, London, W1P 7PP
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Summary

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Eight sera from 125 cases of infectious mononucleosis (IM) were reactive for rubella-specific IgM in an M-antibody capture radioimmunoassay. The reactivity of individual sera varied depending upon the source of the rubella antigen used in the assay. One serum gave strongly positive results with some rubella haemagglutinating antigens but negative results with others and may have contained an IgM antibody which was capable of distinguishing between strains of rubella virus.

If the diagnosis of rubella is based solely on detection in solid-phase immunoassay of rubella-specific IgM, IM should be excluded.

Type
Research Article
Information
Journal of Hygiene , Volume 90 , Issue 3 , June 1983 , pp. 407 - 413
Copyright
Copyright © Cambridge University Press 1983

References

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