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Rubella vaccines: past, present and future

Published online by Cambridge University Press:  15 May 2009

J. M. Best
J. M. Best
Affiliation:
Department of Virology, United Medical and Dental Schools and Guy's and St Thomas's Hospitals, St Thomas' Campus, Lambeth Palace Rd, London SE1 7EH
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The association between rubella in pregnancy and congenital anomalies was first reported 50 years ago, by N. McAlister Gregg, an Australian ophthalmologist [1]. During the next 20 years his findings were confirmed by others (reviewed in [2]). However, the first reports of the isolation of rubella virus in cell cultures and development of tests for neutralizing antibodies were not published until 1962 [3, 4]. Subsequent studies conducted in the UK and North America during a pandemic of rubella in 1963–4, were therefore able to make a more accurate estimate of the risks of maternal rubella at different stages of pregnancy. It was estimated that about 30000 rubella-damaged babies were born in the USA alone in 1963–4 [5]. This emphasized the importance of developing a vaccine to prevent infection in pregnancy and thereby, the birth of babies with rubella-induced congenital defects.

Type
Research Article
Information
Epidemiology & Infection , Volume 107 , Issue 1 , August 1991 , pp. 17 - 30
Copyright
Copyright © Cambridge University Press 1991

References

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