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Responses of volunteers to inactivated influenza virus vaccines

Published online by Cambridge University Press:  25 March 2010

R. Jennings ,
C. W. Potter ,
P. M. O. Massey ,
B. I. Duerden ,
J. Martin  and
A. M. Bevan
R. Jennings
Affiliation:
Department of Virology, University of Sheffield Medical School, Beech Hill Road, Sheffield S10 2RX
C. W. Potter
Affiliation:
Department of Virology, University of Sheffield Medical School, Beech Hill Road, Sheffield S10 2RX
P. M. O. Massey
Affiliation:
Regional Medical Advisor, Central Electricity Generating Board, Haslucks Green Road, Shirley, Solihull, Warwickshire
B. I. Duerden
Affiliation:
Department of Medical Microbiology and Department of Medicine, University of Sheffield Medical School, Beech Hill Road, Sheffield S10 2RX
J. Martin
Affiliation:
Department of Medical Microbiology and Department of Medicine, University of Sheffield Medical School, Beech Hill Road, Sheffield S10 2RX
A. M. Bevan
Affiliation:
Glaxo Operations (U.K.) Ltd, Speke Biologicals, Speke, Liverpool L24 9JD
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Summary

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Three different types of bivalent influenza virus vaccine, a whole virus, an aqueous-surface-antigen vaccine and an adsorbed-surface-antigen vaccine were tested at three dosage levels in volunteers primed with respect to only one of the haemagglutinin antigens present in the vaccines.

The local and systemic reactions to all three vaccine types were mild in nature and, following first immunization, the aqueous-surface-antigen vaccine was the least reactogenic. The serum haemagglutination-inhibiting antibody response to the A/Victoria/75 component of the vaccines, to which the volunteer population was primed, was greatest following immunization with the aqueous-surface-antigen vaccine; the greatest antibody response to the A/New Jersey/76 component of the vaccines was observed following immunization with whole virus vaccine.

Type
Research Article
Information
Journal of Hygiene , Volume 86 , Issue 1 , February 1981 , pp. 1 - 16
Copyright
Copyright © Cambridge University Press 1981

References

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