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A respirometer technique for estimating germicidal activity on skin

Published online by Cambridge University Press:  15 May 2009

R. C. S. Woodroffe
R. C. S. Woodroffe
Affiliation:
Unilever Research Laboratory, Colworth House, Sharnbrook, Bedfordshire
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1. A technique for measuring the antibacterial activity of germicides on pig skin in micro-respirometers has been described.

2. Using this technique the activity of the following germicides has been estimated: 2,2-dihydroxy, 3,5,6,3′,5′,6′-hexachlorodiphenylmethane, 3,4,4′-trichlorocarbanilide, 3,5,4′tribromosalicylanilide, 2,2′-thiobis (4,6-dichlorophenol), Irgasan CF3*, 3,5,3′,4′-tetrachlorosalicylanilide.

3. The results obtained have been discussed in relation to hand-washing test results (Hurst et al. 1960).

Type
Research Article
Information
Journal of Hygiene , Volume 61 , Issue 3 , September 1963 , pp. 283 - 290
Copyright
Copyright © Cambridge University Press 1963

References

REFERENCES

Adams, J. B. (1958). The mode of action of chlorinated bisphenol antibacterials. Part I. Metal chelates of hexachlorophene and thiobisdichlorophenol. J. Pharm., Lond., 10, 507.CrossRefGoogle Scholar
Adams, J. B. & Hobbs, M. (1958). The mode of action of chlorinated bisphenol antibacterials. Part II. Biological studies. J. Pharm., Lond., 10, 516.CrossRefGoogle Scholar
Bechtold, C. L., Lawrence, E. A. & Owen, E. M. (1955). In vitro test for predicting the effectiveness of antibacterial agents in soap. Proc. Sci. Sect. Toilet Goods Ass. no. 24, 21.Google Scholar
Compeau, G. M. (1960). The adsorption of dodecylbenzenesulfonate and hexachlorophene on skin. J. Amer. pharm. Ass. (Sci. ed.), 49, 574.CrossRefGoogle Scholar
Cruickshank, C. N. D. (1954). Continuous observation of the respiration of skin in vitro. Exp. Cell. Res. 7, 374.Google Scholar
Fahlberg, W. J., Swan, J. C. & Seastone, C. V. (1948). Studies on the retention of hexachlorophene (G11) in human skin. J. Bact. 56, 323.CrossRefGoogle ScholarPubMed
Gould, B. S., Bosniak, M. A., Niedleman, S. & Gatt, S. (1953). Effect of hexachlorophene and related bisphenolic compounds on the dehydrogenases and cytochrome system of Bacillus subtilis and Escherichia coli. Arch. Biochim. Biophys. 44, 284.CrossRefGoogle ScholarPubMed
Gould, B. S., Frigerio, N. A. & Lebowitz, W. B. (1955). The action of bisphenolic compounds on succinoxidase, cytochrome c oxidase, and lactic dehydrogenase of animal tissue. Arch. Biochim. Biophys. 56, 476.CrossRefGoogle ScholarPubMed
Hare, R. & Ridley, M. (1958). Further studies on the transmission of Staphylococcus aureus. Brit. med. J. i, 69.CrossRefGoogle Scholar
Hare, R. & Thomas, C. G. A. (1956). The transmission of Staphylococcus aureus. Brit. med. J. ii, 240.Google Scholar
Hurley, H. J. & Shelley, W. B. (1960). The Human Apocrine Sweat Gland in Health and Disease, p. 81. Oxford: Blackwell Scientific Publications.Google Scholar
Hurst, A., Stuttard, L. W. & Woodroffe, R. C. S. (1960). Disinfectants for use in bar-soaps. J. Hyg., Camb., 58, 159.CrossRefGoogle ScholarPubMed
Joswick, H. L. (1961). Mode of action of hexachlorophene. Ph.D. Dissertation, University of Michigan.Google Scholar
Miles, A. A., Williams, R. E. O. & Clayton-Cooper, R. (1944). The carriage of Staphylococcus (pyogenes) aureus in man and its relation to wound infection. J. Path. Bact. 56, 513.CrossRefGoogle Scholar
Vinson, L. (1961). In vitro tests for measuring antibacterial activity of toilet soaps and detergent bars. J. Pharm. Sci. 50, 827.CrossRefGoogle ScholarPubMed
Wilkinson, D. S. (1961). Photodermatitis due to tetrachlorosalicylanilide. Brit. J. Derm. 73, 213.Google Scholar
Williams, R. E. O. (1946). Skin and nose carriage of bacteriophage types of Staphylococcus aureus. J. Path. Bact. 58, 259.Google Scholar
Woodroffe, R. (1963). The measurement of bacterial respiration on pig skin with micro-respirometers. J. Hyg., Camb., 61, 273.CrossRefGoogle ScholarPubMed