Hostname: page-component-cd9895bd7-jn8rn Total loading time: 0 Render date: 2024-12-22T15:11:59.887Z Has data issue: false hasContentIssue false
  • English
  • Français

Resistance to chloramphenicol and ampicillin in Salmonella johannesburg in Hong Kong: observations over a five-year period 1973-1977

Published online by Cambridge University Press:  15 May 2009

P. Y. Chau ,
W. T. Wong  and
Y. P. Fok
P. Y. Chau
Affiliation:
Department of Microbiology, University of Hong Kong, Queen Mary Hospital Compound, Hong Kong
W. T. Wong
Affiliation:
Department of Microbiology, University of Hong Kong, Queen Mary Hospital Compound, Hong Kong
Y. P. Fok
Affiliation:
Department of Microbiology, University of Hong Kong, Queen Mary Hospital Compound, Hong Kong
Rights & Permissions [Opens in a new window]

Summary

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

Samonella johannesburg has been prevalent in Hong Kong since 1973 and most strains were resistant to a multiplicity of antibiotics. The susceptibility of S. johannesburg strains isolated in a 5-year period from 1973 to 1977 to eight antimicrobial drugs including ampicillin (A), streptomycin (S), tetracycline (T), chloramphenicol (C), Kanamycin (K), sulphadiazine (Su), trimethoprim (Tm) and gentamicin (G) was tested by the agar dilution method. The proportion of strains resistant to chloramphenicol and ampicillin increased steadily during the 5-year period while those resistant to tetracycline decreased dramatically. This change was associated with an alteration of predominant patterns of antibiotic resistance: strains with the resistance pattern A.S.T.C.K.Su predominated in years 1973, 1974 and 1975 while those with the resistance pattern A.S.C.K.Su predominated in years 1976 and 1977. Analysis of the resistance patterns of S. johannesburg strains isolated from the same cases showed that the resistance pattern A.S.C.K.Su was more stable, and changed less frequently to other patterns of resistance than strains with the resistance pattern A.S.T.C.K.Su. In donor salmonella strains with the A.S.T.C.K.Su resistance pattern, transmissible factorscarrying resistance to A.S.T.C.K.Su in to to, to A.S.T.C.Su, A.T.C.K.Su and to A or T alone were demonstrated. In donor salmonella strains with the A.S.C.K.Su resistance pattern, transmissible factors carrying resistance to A.S.C.K.Su in toto and to A.S.K.Su were detected. The significance of the carriage of such transmissible resistance factors by this Salmonella is briefly discussed.

Type
Research Article
Information
Journal of Hygiene , Volume 81 , Issue 3 , December 1978 , pp. 343 - 351
Copyright
Copyright © Cambridge University Press 1978

References

REFERENCES

Anderson, E. S. (1975). The problem and implication of chloramphenicol resistance in the typhoid bacillus. Journal of Hygiene 74, 289–99.CrossRefGoogle ScholarPubMed
Barry, A. L. (1976). The Antimicrobic Susceptibility Test: Principles and Practice. Philadelphia: Lea & Febiger.Google Scholar
Cherubin, C. E., Neu, H. C., Rahal, J.J & Sabath, L. D. (1977). Emergence of resistance to chloramphenicol in Salmonella. The Journal of Infectious Diseases 135, 807–12.CrossRefGoogle Scholar
Grant, R. B., Bannatyne, R. M. & Shapley, A. J. (1976). Resistance to chloramphenicol and ampicillin of Salmonella typhimurium in Ontario, Canada. The Journal of Infectious Diseases 134, 354–61.CrossRefGoogle ScholarPubMed
McHugh, C. L., Moellering, R. C., Hopkins, C. C. & Swartz, M. N. (1975). Salmonella typhimurium resistant to silver nitrate, chloramphenicol and ampicillin. Lancet i, 235–9.CrossRefGoogle Scholar
Teoh-Chan, C. H., Chau, P. Y., Tse, D., Sin, W. K., Ip, H. M. H. & Lan, R. (1977). Hospital Salmonella johannesburg infection and its possible role in the community spread of the infection in Hong Kong. Journal of Hygiene 78, 113–9.CrossRefGoogle ScholarPubMed