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Resistance of Escherichia coli in faeces and the use of antimicrobial agents in the treatment of hospital patients

Published online by Cambridge University Press:  19 October 2009

J. E. Degener ,
A. C. W. Smit ,
M. F. Michel ,
H. A. Valkenburg  and
L. Muller
J. E. Degener
Affiliation:
Department of Clinical Microbiology and Antimicrobial Therapy, Erasmus University
A. C. W. Smit
Affiliation:
Department of Clinical Microbiology and Antimicrobial Therapy, Erasmus University
M. F. Michel
Affiliation:
Department of Clinical Microbiology and Antimicrobial Therapy, Erasmus University
H. A. Valkenburg
Affiliation:
Department of Epidemiology, Erasmus University, PO Box 1738 3000 DR Rotterdam, The Netherlands
L. Muller
Affiliation:
Department of Epidemiology, Erasmus University, PO Box 1738 3000 DR Rotterdam, The Netherlands
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Resistance of faecal Escherichia coli to ampicillin, tetracycline, sulphamethoxazole and gentamicin was studied in patients admitted to seven different departments in two hospitals. The resistance to ampicillin, tetracycline and sulphamethoxazole in the seven patient groups was 27–57%, 26–56% and 35–63%, respectively. Resistance to gentamicin was found in only one department. An E. coli flora predominantly resistant to ampicillin, tetracycline or sulphamethoxazole (> 50% of the E. coli strains in a faecal sample resistant) was found in 10–38%, 4–30% and 21–35% of the samples. A cross-sectional study focusing on the influence of the use of antimicrobial agents on the occurrence of resistant strains revealed a positive correlation between the annual turnover of broad-spectrum penicillins in various departments and the occurrence of predominantly ampicillin-resistant E. coli strains in these departments.

Type
Research Article
Information
Journal of Hygiene , Volume 91 , Issue 3 , December 1983 , pp. 491 - 498
Copyright
Copyright © Cambridge University Press 1983

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