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The relative natural resistance of rats and mice to experimental pulmonary tuberculosis*

Published online by Cambridge University Press:  15 May 2009

David F. Gray
David F. Gray
Affiliation:
From the School of Microbiology, University of Melbourne, Parkville, N. 2, Victoria, Australia
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1. Wistar-albino rats showed no significant difference from albino mice in their response to pulmonary tuberculosis. This conclusion was reached after a detailed comparison of bacillary multiplication, lung involvement, death rates and the rate of conversion to the immune state as determined by footpad reaction to tuberculin in the two species.

2. These findings support the theory that the key to species differences in resistance to tuberculosis is the rate of onset of acquired immunity and it is therefore unrelated to natural resistance.

Type
Research Article
Information
Journal of Hygiene , Volume 59 , Issue 4 , December 1961 , pp. 471 - 478
Copyright
Copyright © Cambridge University Press 1961

References

Gray, D. F. (1959). Fate of tubercle bacilli in early experimental infection of the mouse. J. Hyg., Camb., 57, 473.Google Scholar
Gray, D. F., Graham-Smith, H. & Noble, J. L. (1960). Variations in natural resistance to tuberculosis. J. Hyg., Camb., 58, 215.Google Scholar
Gray, D. F. & Mattinson, M. M. (1952). Detection of small numbers of tubercle bacilli from dispersed cultures using mice, guinea pigs and artificial media. Amer. Rev. Tuberc. 69, 92.Google Scholar
Gray, D. F., Noble, J. L. & O'Hara, M. (1961). Allergy in experimental rat tuberculosis J. Hyg., Camb., 59, 427.Google Scholar
Ratcliffe, H. L. & Palladino, V. S. (1953). Tuberculosis induced by droplet nuclei infection. J. Exp. Med. 97, 61.Google Scholar