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The relative immunogenicity in mice of whole and split influenza virus

Published online by Cambridge University Press:  15 May 2009

S. S. Gandhi
S. S. Gandhi
Affiliation:
National Biological Standards Laboratory, Viral Products Section, 45 Poplar Road, Private Bag No. 7, Parkville, Victoria 3052, Australia
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Summary

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The relative immunogenicity in mice of whole influenza virus, and virus split with different disrupting agents, was compared. Using the single radial immunodiffusion test to estimate the haemagglutinin antigen concentration in different virus preparations, it was found that, in general, split virus preparations induced substantially lower titres of HI antibody in mice than whole virus after one or two injections of the antigen.

Type
Research Article
Information
Journal of Hygiene , Volume 81 , Issue 3 , December 1978 , pp. 337 - 342
Copyright
Copyright © Cambridge University Press 1978

References

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