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The relationship between faecal endotoxin and faecal microflora of the C57BL mouse

Published online by Cambridge University Press:  19 October 2009

M. J. Rogers ,
R. Moore  and
J. Cohen
M. J. Rogers
Affiliation:
Departments of Medicine and Bacteriology, Royal Postgraduate Medical School, Hammersmith Hospital, Du Cane Rd, London W12 0HS
R. Moore
Affiliation:
Departments of Medicine and Bacteriology, Royal Postgraduate Medical School, Hammersmith Hospital, Du Cane Rd, London W12 0HS
J. Cohen
Affiliation:
Departments of Medicine and Bacteriology, Royal Postgraduate Medical School, Hammersmith Hospital, Du Cane Rd, London W12 0HS
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We studied the effect of oral selective antibiotic decontamination (SD) on the faecal endotoxin content and microflora in individual C57BL mice. Suppression of the coliform count was associated with an initial rise in faecal endotoxin concentration from 0·1 to 3·1 mg/g wet faeces during the first week of SD, which fell to 0·04 mg/g during the second week of treatment. Cessation of SD resulted in an immediate sharp increase in coliform count followed by its decline and gradual recovery to pro-treatment counts. Faecal endotoxin levels followed a parallel course. SD did not effect significantly the counts of lactobacilli, baeteroides and enterococci.

It appears that the coliform population is responsible for the overall level of faecal endotoxin, and that during the initial period of SD endotoxin levels are elevated, an effect which may be mediated by antibiotic-enhanced release of endotoxin.

Type
Research Article
Information
Journal of Hygiene , Volume 95 , Issue 2 , October 1985 , pp. 397 - 402
Copyright
Copyright © Cambridge University Press 1985

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