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Re-emergence of meningococcal disease in Taiwan: circulation of domestic clones of Neisseria meningitidis in the 2001 outbreak

Published online by Cambridge University Press:  09 July 2004

P.-R. HSUEH ,
L.-J. TENG ,
T.-Y. LIN ,
K.-T. CHEN ,
H.-M. HSU ,
S.-J. TWU ,
S.-W. HO  and
K.-T. LUH
P.-R. HSUEH
Affiliation:
Department of Laboratory Medicine, National Taiwan University Hospital, Taipei, Taiwan Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan
L.-J. TENG
Affiliation:
Department of Laboratory Medicine, National Taiwan University Hospital, Taipei, Taiwan School of Medical Technology, National Taiwan University College of Medicine, Taipei, Taiwan
T.-Y. LIN
Affiliation:
Chang Gung Childrens Hospital, Taoyuan, Taiwan
K.-T. CHEN
Affiliation:
Center for Disease Control, Department of Health, Taiwan
H.-M. HSU
Affiliation:
Center for Disease Control, Department of Health, Taiwan
S.-J. TWU
Affiliation:
Center for Disease Control, Department of Health, Taiwan
S.-W. HO
Affiliation:
Department of Laboratory Medicine, National Taiwan University Hospital, Taipei, Taiwan School of Medical Technology, National Taiwan University College of Medicine, Taipei, Taiwan
K.-T. LUH
Affiliation:
Department of Laboratory Medicine, National Taiwan University Hospital, Taipei, Taiwan Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan
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Abstract

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The annual incidence of meningococcal disease (meningitis and septicaemia) in Taiwan was 0·94/105 population in 1953. It then declined to below 0·001 from 1980 to 1987, and re-emerged in 2000 with a rate of 0·07/105 population. In 2001 there was a further increase in incidence (43 cases, 0·19/105). Of 43 isolates of Neisseria meningitidis available for this study, including 41 from patients treated in 2001, three (7·0%) were penicillin insensitive (MIC [ges ]0·12 μg/ml), though all were β-lactamase negative; 16 (37·2%) were resistant to trimethoprim–sulphamethoxazole sulphamethoxazole (MIC [ges ]4/76 μg/ml). Serogrouping and genotype analysis revealed nine domestic clones. None of the 43 patients had any relationship (travel or contact history) with the 2000 or 2001 Hajj pilgrimage. Epidemiological information and typing results suggested wide dissemination of a limited number of domestic clones of N. meningitidis, manifesting as serogroups W-135, B and Y. Two clones of serogroup W-135 involved in the outbreak were genetically distinct from the 2000 or 2001 Hajj-related W-135 clone.

Type
Research Article
Information
Epidemiology & Infection , Volume 132 , Issue 4 , August 2004 , pp. 637 - 645
Copyright
2004 Cambridge University Press