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R plasmids conferring multiple drug resistance from shigella isolated in Korea

Published online by Cambridge University Press:  19 October 2009

Doki Chun ,
Dong Taek Cho ,
Sung Yong Seol ,
Min Ho Suh  and
Yoo Chul Lee
Doki Chun
Affiliation:
Department of Microbiology, Keimyung University School of Medicine, Taegu, Republic of Korea
Dong Taek Cho
Affiliation:
Department of Microbiology, Kyungpook National University School of Medicine, Taegu, Republic of Korea
Sung Yong Seol
Affiliation:
Department of Microbiology, Kyungpook National University School of Medicine, Taegu, Republic of Korea
Min Ho Suh
Affiliation:
Department of Microbiology, Kyungpook National University School of Medicine, Taegu, Republic of Korea
Yoo Chul Lee
Affiliation:
Department of Microbiology, Kyungpook National University School of Medicine, Taegu, Republic of Korea
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The majority (85%) of shigella isolated in 1980 and 1981 in Korea were Shigella flexneri, the others were Sh. sonnei (14%) with only a small number of Sh. dysenteriae. Only 14 of the 459 strains of shigella isolated were susceptible to all 12 drugs tested, and 445 were resistant to three or more drugs. Strains multiply resistant to the six drugs, chloramphenicol (Cm), tetracycline (Tc), streptomycin (Sm), sulfisomidine (Su), ampicillin (Ap) and trimethoprim (Tp) were most frequently encountered, followed by those resistant to Cm, Tc, Sm, Su and Tp. The complete patterns of resistance to drugs except nalidixic acid and rifampin in approximately 73% of drug-resistant strains were co-transferred to Escherichia coli by conjugation, indicating that the resistance was R plasmid-mediated. Randomly selected R plasmids conferring various patterns of resistance markers were tested for the incompatibility groups, and almost all of them were classified into Inc FII. Two of three R plasmids conferring resistance to Cm, Tc, Sm and Su were classified into Inc B and one to Inc FII. Two R types with resistance markers of Cm, Tc, Sm and Ap were not classified with our standard plasmids used.

Type
Research Article
Information
Journal of Hygiene , Volume 92 , Issue 2 , April 1984 , pp. 153 - 160
Copyright
Copyright © Cambridge University Press 1984

References

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