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The Q Proteins and Non-Specific O-Antigens of the Cholera Vibrio

Published online by Cambridge University Press:  15 May 2009

P. Bruce White
P. Bruce White
Affiliation:
From the National Institute for Medical Research, London
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Vibrios heated at 100°C. in saline suspension agglutinate in a generalised manner and often to a high titre with the antisera of the Q proteins of the cholera vibrio. The antibodies concerned are not inactivated by the carbohydrate fraction of V. cholerae. Occasional strains of vibrio react similarly in the living state with these Q (choiera) agglutinins. The antiserum of the Q2 substance of S V. cholerae seems to possess agglutinating properties additional to those of anti-Q1 and anti-Q2 R sera, rather more specific and possibly related to “carbohydrate” receptors. There is reason to believe that the Q proteins are true constituents of the living vibrio and are not serological artefacts due to reagents and heat. It seems that these substances and their antibodies are important contributors to the “non-specific O agglutination” of vibrios recently discussed by Gardner and Venkatraman.

Type
Research Article
Information
Journal of Hygiene , Volume 35 , Issue 4 , December 1935 , pp. 498 - 503
Copyright
Copyright © Cambridge University Press 1935

References

REFERENCES

Gardner, A. D. and Venkatraman, K. V. (1935). J. Hygiene, 35, 262.CrossRefGoogle Scholar
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Linton, R. W., Harwant, Singh J. and Seal, S. C. (1935). Ibid 22, 65.CrossRefGoogle Scholar
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