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Purified Vero cell rabies vaccine and human diploid cell strain vaccine: comparison of neutralizing antibody responses to post-exposure regimens

Published online by Cambridge University Press:  19 October 2009

Pravan Suntharasamai ,
Pornthep Chanthavanich ,
M. J. Warrell ,
Sornchai Looareesuwan ,
Juntra Karbwang ,
Wichai Supanaranond ,
R. E. Phillips ,
Weerapol Jansawan ,
C. Xueref  and
X. Pouradier-Duteil
...Show all authors
Pravan Suntharasamai
Affiliation:
Hospital for Tropical Diseases, Faculty of Tropical Medicine, Mahidol University, Bangkok; Sir William Dunn School of Pathology and Nuffield Department of Clinical Medicine, University of Oxford; Liverpool School of Tropical Medicine, Liverpool; Institut Méerieux, Lyons, France; and Faculty of Veterinary Medicine, Kasetsart University, Bangkok
Pornthep Chanthavanich
Affiliation:
Hospital for Tropical Diseases, Faculty of Tropical Medicine, Mahidol University, Bangkok; Sir William Dunn School of Pathology and Nuffield Department of Clinical Medicine, University of Oxford; Liverpool School of Tropical Medicine, Liverpool; Institut Méerieux, Lyons, France; and Faculty of Veterinary Medicine, Kasetsart University, Bangkok
M. J. Warrell
Affiliation:
Hospital for Tropical Diseases, Faculty of Tropical Medicine, Mahidol University, Bangkok; Sir William Dunn School of Pathology and Nuffield Department of Clinical Medicine, University of Oxford; Liverpool School of Tropical Medicine, Liverpool; Institut Méerieux, Lyons, France; and Faculty of Veterinary Medicine, Kasetsart University, Bangkok
Sornchai Looareesuwan
Affiliation:
Hospital for Tropical Diseases, Faculty of Tropical Medicine, Mahidol University, Bangkok; Sir William Dunn School of Pathology and Nuffield Department of Clinical Medicine, University of Oxford; Liverpool School of Tropical Medicine, Liverpool; Institut Méerieux, Lyons, France; and Faculty of Veterinary Medicine, Kasetsart University, Bangkok
Juntra Karbwang
Affiliation:
Hospital for Tropical Diseases, Faculty of Tropical Medicine, Mahidol University, Bangkok; Sir William Dunn School of Pathology and Nuffield Department of Clinical Medicine, University of Oxford; Liverpool School of Tropical Medicine, Liverpool; Institut Méerieux, Lyons, France; and Faculty of Veterinary Medicine, Kasetsart University, Bangkok
Wichai Supanaranond
Affiliation:
Hospital for Tropical Diseases, Faculty of Tropical Medicine, Mahidol University, Bangkok; Sir William Dunn School of Pathology and Nuffield Department of Clinical Medicine, University of Oxford; Liverpool School of Tropical Medicine, Liverpool; Institut Méerieux, Lyons, France; and Faculty of Veterinary Medicine, Kasetsart University, Bangkok
R. E. Phillips
Affiliation:
Hospital for Tropical Diseases, Faculty of Tropical Medicine, Mahidol University, Bangkok; Sir William Dunn School of Pathology and Nuffield Department of Clinical Medicine, University of Oxford; Liverpool School of Tropical Medicine, Liverpool; Institut Méerieux, Lyons, France; and Faculty of Veterinary Medicine, Kasetsart University, Bangkok
Weerapol Jansawan
Affiliation:
Hospital for Tropical Diseases, Faculty of Tropical Medicine, Mahidol University, Bangkok; Sir William Dunn School of Pathology and Nuffield Department of Clinical Medicine, University of Oxford; Liverpool School of Tropical Medicine, Liverpool; Institut Méerieux, Lyons, France; and Faculty of Veterinary Medicine, Kasetsart University, Bangkok
C. Xueref
Affiliation:
Hospital for Tropical Diseases, Faculty of Tropical Medicine, Mahidol University, Bangkok; Sir William Dunn School of Pathology and Nuffield Department of Clinical Medicine, University of Oxford; Liverpool School of Tropical Medicine, Liverpool; Institut Méerieux, Lyons, France; and Faculty of Veterinary Medicine, Kasetsart University, Bangkok
X. Pouradier-Duteil
Affiliation:
Hospital for Tropical Diseases, Faculty of Tropical Medicine, Mahidol University, Bangkok; Sir William Dunn School of Pathology and Nuffield Department of Clinical Medicine, University of Oxford; Liverpool School of Tropical Medicine, Liverpool; Institut Méerieux, Lyons, France; and Faculty of Veterinary Medicine, Kasetsart University, Bangkok
D. A. Warrell
Affiliation:
Hospital for Tropical Diseases, Faculty of Tropical Medicine, Mahidol University, Bangkok; Sir William Dunn School of Pathology and Nuffield Department of Clinical Medicine, University of Oxford; Liverpool School of Tropical Medicine, Liverpool; Institut Méerieux, Lyons, France; and Faculty of Veterinary Medicine, Kasetsart University, Bangkok
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Neutralizing antibody responses to conventional rabies post-exposure regimens of human diploid cell strain vaccine (HDCSV) and the new purified Vero cell rabies vaccine (PVRV) were compared in 58 healthy Thai veterinary students. The geometric mean titres (GMTs) of the group given HDCSV were slightly higher than those given PVRV, but on day 28 the peak GMTs of the two groups were statistically similar. The early antibody response to PVRV was unaffected by the addition of passive immunization, whereas the level of HDCSV response was reduced on day 14, so that there was no difference on that day between the GMTs of the two vaccine groups given HRIG. However, by day 91 the GMT of those given PVRV and HRIG was lower than in those given HDCSV alone or with HRIG. The appearance of antibody was less rapid than was observed in previous studies using multiple-site intradermal vaccination. Side effects were trivial. Our results confirm the promise of this new, potentially more economical tissue culture vaccine, but they suggest that the regimen could be improved.

Type
Research Article
Information
Journal of Hygiene , Volume 96 , Issue 3 , June 1986 , pp. 483 - 489
Copyright
Copyright © Cambridge University Press 1986

References

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