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Protection from natural infection after live influenza virus immunization in an open population*

Published online by Cambridge University Press:  15 May 2009

G. Rocchi ,
L. Carlizza ,
M. Andreoni ,
G. Ragona ,
C. Piga ,
A. Pelosio ,
A. Volpi  and
A. Muzzi
G. Rocchi
Affiliation:
Third Medical Clinic, University of Rome, 00161 Rome, Italy
L. Carlizza
Affiliation:
Third Medical Clinic, University of Rome, 00161 Rome, Italy
M. Andreoni
Affiliation:
Third Medical Clinic, University of Rome, 00161 Rome, Italy
G. Ragona
Affiliation:
Third Medical Clinic, University of Rome, 00161 Rome, Italy
C. Piga
Affiliation:
Third Medical Clinic, University of Rome, 00161 Rome, Italy
A. Pelosio
Affiliation:
Third Medical Clinic, University of Rome, 00161 Rome, Italy
A. Volpi
Affiliation:
Third Medical Clinic, University of Rome, 00161 Rome, Italy
A. Muzzi
Affiliation:
Institute of Hygiene, University of Rome
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Summary

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Live attenuated influenza vaccine containing the recombinant of A/Victoria/3/75 with A/PR/8/34 virus was administered to healthy adults in a field trial aimed at evaluating protection provided by immunization. The study was designed to measure the effect of vaccination on absenteeism from respiratory disease during a natural influenza epidemic. A total of 2115 male employees of the public transport service of Rome volunteered to participate in the trial, 1050 and 1065 receiving vaccine and placebo respectively, in a randomized blind fashion. Vaccination procedure was completed by the end of December 1976. A small-sized outbreak of influenza, due to a viral strain antigenically homologous to the vaccine, occurred during the month of February 1977. Analysis of absenteeism data, classified according to medical certificate, indicated that morbidity from respiratory disease was reduced in vaccinees compared with controls during the epidemic month; the rate of increase of morbidity compared with that of the preceding month was then three times lower in vaccinees than in controls and the difference in absenteeism between the two groups greatly exceeded the ordinary fluctuation that was observed during non-epidemic periods.

Type
Research Article
Information
Journal of Hygiene , Volume 82 , Issue 2 , April 1979 , pp. 231 - 236
Copyright
Copyright © Cambridge University Press 1979

References

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