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Protection against experimental infection with influenza virus A/equine/Miami/63 (H3N8) provided by inactivated whole virus vaccines containing homologous virus

Published online by Cambridge University Press:  19 October 2009

J. A. Mumford ,
J. M. Wood ,
C. Folkers  and
G. C. Schild
J. A. Mumford
Affiliation:
Equine Virology Unit, Animal Health Trust, Lanwades Park, Kennett, Newmarket, Suffolk, CB8 7PN
J. M. Wood
Affiliation:
Division of Viral Products, National Institute for Biological Standards and Control, Clare Hall, Blanche Lane, South Mimms, Potters Bar, Herts, ENG 3QG
C. Folkers
Affiliation:
Animal Health Division, Duphar BV, c.j. Van Houlenlaan 36, 1381 cp Weesp, Holland
G. C. Schild
Affiliation:
Division of Viral Products, National Institute for Biological Standards and Control, Clare Hall, Blanche Lane, South Mimms, Potters Bar, Herts, ENG 3QG
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Summary

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Thirty-one ponies immunized with inactivated virus vaccine containing A/equine/Miami/63 (H3N8) virus and six seronegative ponies were experimentally challenged with the homologous virus strain. All G unvaccinated ponies and 11 out of 31 vaccinated ponies became infected. A clear relationship between pre-challenge antibody, measured by single radial haemolysis (SRH), and protection was demonstrated as judged by virus excretion, febrile responses and antibody responses. Those ponies with SRH antibody levels > 74 mm2 were completely protected against challenge infection by the intranasal route.

Type
Research Article
Information
Epidemiology & Infection , Volume 100 , Issue 3 , June 1988 , pp. 501 - 510
Copyright
Copyright © Cambridge University Press 1988

References

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