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Prognostic factors for the long-term development of ocular lesions in 327 children with congenital toxoplasmosis

Published online by Cambridge University Press:  23 December 2003

C. BINQUET ,
M. WALLON ,
C. QUANTIN ,
L. KODJIKIAN ,
J. GARWEG ,
J. FLEURY ,
F. PEYRON  and
M. ABRAHAMOWICZ
C. BINQUET
Affiliation:
Laboratoire de Biostatistique, INSERM EPI 01-06, Faculté de Médecine, 7 bd Jeanne d'Arc, 21000 Dijon, France
M. WALLON
Affiliation:
Service de Parasitologie, Hôpital de la Croix-Rousse, 103 grande rue de la Croix-Rousse, 69004 Lyon, France
C. QUANTIN
Affiliation:
Laboratoire de Biostatistique, INSERM EPI 01-06, Faculté de Médecine, 7 bd Jeanne d'Arc, 21000 Dijon, France
L. KODJIKIAN
Affiliation:
Service d'Ophtalmologie, Hôpital de la Croix-Rousse, 103 grande rue de la Croix-Rousse, 69004 Lyon, France
J. GARWEG
Affiliation:
Department of Ophthalmology, University of Bern, Inselspital, CH 3010 Bern, Switzerland
J. FLEURY
Affiliation:
Service d'Ophtalmologie, Hôpital de la Croix-Rousse, 103 grande rue de la Croix-Rousse, 69004 Lyon, France
F. PEYRON
Affiliation:
Service de Parasitologie, Hôpital de la Croix-Rousse, 103 grande rue de la Croix-Rousse, 69004 Lyon, France
M. ABRAHAMOWICZ
Affiliation:
Department of Epidemiology and Biostatistics, McGill University, Division of Clinical Epidemiology, Montreal General Hospital, 1650 Cedar Avenue, Montreal, Quebec, Canada H3A 1A2
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Abstract

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The aim of this study was to identify the high-risk factors associated with the development of ocular lesions in a large cohort of children with congenital toxoplasmosis (CT), irrespective of their gestational age at the time of maternal infection. Children were managed according to a standardized protocol and monitored for up to 14 years at the Croix-Rousse Hospital, Lyon, France. Cox model and a flexible regression, spline-based method were used for the analysis. During a median follow-up time of 6 years, 79 of the 327 children (24%) had at least one retinochoroidal lesion. No bilateral impairment of visual acuity was observed. The risk of a child developing ocular disease was higher not only when mothers were infected early during pregnancy, which was expected, but also when CT was diagnosed prior to or at the time of birth, when non-ocular manifestations were present at baseline and when birth was premature.

Type
Research Article
Information
Epidemiology & Infection , Volume 131 , Issue 3 , December 2003 , pp. 1157 - 1168
Copyright
2003 Cambridge University Press