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The production of pyrogenic exotoxins by group A streptococci

Published online by Cambridge University Press:  19 October 2009

Gillian Hallas
Gillian Hallas
Affiliation:
Division of Hospital Infection, Central Public Health Laboratory, 61 Colindale Avenue, London NW9 5HT, U.K.
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Summary

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Lancefield group A streptococci isolated from recent outbreaks and sporadic cases of scarlet fever were restricted to the following M types 1, 3, 4, 6, 12, 18, 22 and 66. These strains were examined for the presence of streptococcal pyrogenic exotoxins (SPE) types A, B and C by isoelectric focusing in polyacrylamide gels and by immunoprecipitation in agar gels. SPE B was produced by 70% of the strains and SPEC by 40%. SPE A could not be detected in these strains. In contrast, SPE type A was found in 4 of 10 strains, held by the NCTC, that had been isolated before 1940 from patients with scarlet fever. Nine of 12 recent isolates from patients with sore throat uncomplicated by a rash produced SPE C and 4 of these also produced SPE B.

Type
Research Article
Information
Journal of Hygiene , Volume 95 , Issue 1 , August 1985 , pp. 47 - 57
Copyright
Copyright © Cambridge University Press 1985

References

REFERENCES

Bloomster, T. G. & Watson, D. W. (1982). Recent trends in streptococcal pyrogenic exotoxin production by group-A streptococci. In Basic Concepts of Streptococci and Streplococcal Diseases (ed. Holm, S. E. & Christensen, P.), pp. 139–141. Chertsey: Reedbooks Ltd.Google Scholar
Gerlach, D., Köhler, W. & Knöll, H. (1982). Comparison of erythrogenic toxins produced by Streptococcus pyogenes. In Basic Concepts of Streptococci and Streplococcal Diseases (ed. Holm, S.E. & Christensen, P.) pp. 137–138. Chertsey: Reedbooks Ltd.Google Scholar
Griffith, F. (1934). The serological classification of Streptococcus pyogenes. Journal of Hygiene 34, 542–584.Google ScholarPubMed
Hallas, G. & Widdowson, J. P. (1983). The relationship between opacity factor and M protein in Streptococcus pyogenes. Journal of Medical Microbiology 16, 13–26.CrossRefGoogle Scholar
Harboe, N. & Ingild, A. (1973). Immunization, isolation of immunoglobulins, estimation of antibody titre. Scandinavian Journal of Immunology 2, Suppl. no. 1, p. 162.CrossRefGoogle Scholar
Hooker, S. B. & Follensby, E. M. (1934). Studies on scarlet fever. II. Different toxins produced by hemolytic streptococci of scarlatinal origin. Journal of Immunology 27, 177–193.CrossRefGoogle Scholar
Kaneko, Y., Murai, T., Yata, J., Okuda, R., Tupasi, T. E., Reyes, A. L., Ramos, C. P. & Antonio-Velmonte, M. (1979). Streptococci prevalent in Manila, the Philippines. In Pathogenic Streptococci (ed. Parker, M. T.), pp. 110–111. Chertsey: Reedbooks Ltd.Google Scholar
Kim, Y. B. & Watson, D. W. (1970). A purified group A streptococcal pyrogenic exotoxin. Physicochemical and biological properties including the enhancement of susceptibility to endotoxin lethal shock. Journal of Experimental Medicine 131, 611–628.Google Scholar
MacGregor, J. D. (1980). Scarlet feverin Shetland: December 1979 to April 1980. Communicable Diseases Scotland 21, vii–ix.Google Scholar
Office of Population Censuses and Surveys. Communicable Disease Surveillance Centre of the Public Health Laboratory Service (1982). In Communicable Disease Statistics Series MH2 No. 9, pp. 6–7. London: HMSO.Google Scholar
Parker, M. T. (1967). International survey of the distribution of serotypes of Streptococcus pyogenes (group A streptococci). Bulletin of the World Health Organisation 37, 513–527.Google ScholarPubMed
Perks, E. M. & Mayon-White, R. T. (1983). The incidence of scarlet fever. Journal of Hygiene 91, 203–209.CrossRefGoogle ScholarPubMed
Quinn, R. W. (1982). Epidemiology of group A streptococcal infections – their changing frequency and severity. Yale Journal of Biology and Medicine 55, 265–270.Google ScholarPubMed
Report, (1954). Monthly Bulletin of the. Ministry of Health and the Public Health Laboratory Service 13, 171–174.Google Scholar
Report (1957). Monthly Bulletin of the Ministry of Health and Public Health Laboratory Service 16, 163–172.Google Scholar
Schlievert, P. M., Bettin, K. M. & Watson, D. W. (1979). Production of pyrogenie exotoxin by groups of streptococci: association with group A. Journal of Infectious Diseases 140, 676–681.CrossRefGoogle ScholarPubMed
Van de Rijn, I. & Kessler, R. E. (1980). Growth characteristics of group A streptococci in a new chemically defined medium. Infection and Immunity 27, 444–448.CrossRefGoogle Scholar
Watson, D. W. (1979). Characterisation and pathobiological properties of group-A streptoeoccal pyrogenic exotoxins. In Pathogenic Streptococci, (ed. Parker, M. T.), pp. 62–63. Chertsey: Reedbooks Ltd.Google Scholar
Watson, D. W. & Kim, Y. B. (1970). Erythrogenic toxins. In Microbial Toxins, vol. III. Bacterial Protein Toxins (ed. Montie, T. C., Kadis, S. and Ajl, S. J.), pp. 173–187. New York: Academic Press.Google Scholar