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The production of pyrogenic exotoxins by group A streptococci

Published online by Cambridge University Press:  19 October 2009

Gillian Hallas
Gillian Hallas
Affiliation:
Division of Hospital Infection, Central Public Health Laboratory, 61 Colindale Avenue, London NW9 5HT, U.K.
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Summary

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Lancefield group A streptococci isolated from recent outbreaks and sporadic cases of scarlet fever were restricted to the following M types 1, 3, 4, 6, 12, 18, 22 and 66. These strains were examined for the presence of streptococcal pyrogenic exotoxins (SPE) types A, B and C by isoelectric focusing in polyacrylamide gels and by immunoprecipitation in agar gels. SPE B was produced by 70% of the strains and SPEC by 40%. SPE A could not be detected in these strains. In contrast, SPE type A was found in 4 of 10 strains, held by the NCTC, that had been isolated before 1940 from patients with scarlet fever. Nine of 12 recent isolates from patients with sore throat uncomplicated by a rash produced SPE C and 4 of these also produced SPE B.

Type
Research Article
Information
Journal of Hygiene , Volume 95 , Issue 1 , August 1985 , pp. 47 - 57
Copyright
Copyright © Cambridge University Press 1985

References

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