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The production and preliminary investigation of Burulin, a new skin test reagent for Mycobacterium ulcerans infection

Published online by Cambridge University Press:  15 May 2009

J. L. Stanford ,
W. D. L. Revill ,
W. J. Gunthorpe  and
J. M. Grange
J. L. Stanford
Affiliation:
School of Pathology, Middlesex Hospital Medical School, Riding House Street, London W 1P 7LD
W. D. L. Revill
Affiliation:
School of Pathology, Middlesex Hospital Medical School, Riding House Street, London W 1P 7LD
W. J. Gunthorpe
Affiliation:
School of Pathology, Middlesex Hospital Medical School, Riding House Street, London W 1P 7LD
J. M. Grange
Affiliation:
School of Pathology, Middlesex Hospital Medical School, Riding House Street, London W 1P 7LD
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Summary

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The preparation of a skin test antigen from Mycobacterium ulcerans by ultrasonic disintegration and filtration is described. The reagent, called Burulin, was tested in Africa in normal school children, and in patients with leprosy, tuberculosis or M. ulcerans disease. Those with tuberculosis or M. ulcerans disease were simultaneously tested with Tuberculin PPD. Burulin was found to be highly specific for patients in the reactive stage of M. ulcerans disease, and there was no cross-reaction in patients with other mycobacterioses. On the other hand, the majority of patients with M. ulcerans disease reacting to Burulin also produce positive reactions to Tuberculin PPD.

Type
Research Article
Information
Journal of Hygiene , Volume 74 , Issue 1 , February 1975 , pp. 7 - 16
Copyright
Copyright © Cambridge University Press 1975

References

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