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Prevalence of hepatitis A virus infection among sewage workers in Singapore

Published online by Cambridge University Press:  15 May 2009

B. H. Heng ,
K. T. Goh ,
S. Doraisingham  and
G. H. Quek
B. H. Heng
Affiliation:
Institute of Environmental Epidemiology, Ministry of the Environment, Environment Building #22–00, 40 Scotts Road, Singapore 0922
K. T. Goh
Affiliation:
Institute of Environmental Epidemiology, Ministry of the Environment, Environment Building #22–00, 40 Scotts Road, Singapore 0922
S. Doraisingham
Affiliation:
Department of Pathology, Singapore General Hospital, Outram Road, Singapore0316
G. H. Quek
Affiliation:
Institute of Environmental Epidemiology, Ministry of the Environment, Environment Building #22–00, 40 Scotts Road, Singapore 0922
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Summary

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To determine whether or not occupational exposure to sewage is associated with a higher seroprevalence of hepatitis A virus (HAV) infection, 600 sewage workers in Singapore were tested for total (IgG and IgM) antibody to HAV by enzyme immunoassay. Using logistic regression with stepwise procedure, the adjusted seroprevalence of sewage workers was 2·2 times higher than that of another non-occupationally exposed population group. Seroprevalence was significantly correlated with age and educational levels, the association being independent of the occupational association. The epidemiological data in the study show that sewage workers have an increased occupational risk of acquiring HAV infection and should be protected by active immunization.

Type
Research Article
Information
Epidemiology & Infection , Volume 113 , Issue 1 , August 1994 , pp. 121 - 128
Copyright
Copyright © Cambridge University Press 1994

References

REFERENCES

1.Goh, KT, Wong, LYM, Oon, CJ, Kumarapathy, S. The prevalence of antibody to hepatitis A virus in Singapore. Asia-Pacific J Pub Hlth 1987; 1: 9–11.Google Scholar
2.Yap, I, Guan, R. Hepatitis A sero-prevalence in Singapore: a changing pattern. Trans Roy Soc Trop Med Hyg 1983; 87: 22–3.CrossRefGoogle Scholar
3.Committee on Epidemic Diseases. Epidemiology of hepatitis A virus infection in Singapore. Epidemiol News Bull 1992; 18: 63–4.Google Scholar
4.Goh, KT, Chan, L, Ding, DL, Oon, CJ. An epidemic of cockles-associated hepatitis A in Singapore. Bull WHO 1984; 62: 893–7.Google Scholar
5.Goh, KT, Doraisingham, S, Monteiro, EH, Ling, AE. Acute hepatitis A in Singapore: importance of shellfish ingestion in a non-epidemic period. Ann Acad Med Singapore 1987; 16: 591–4.Google Scholar
6.Bancroft, WH. Hepatitis A vaccine. New Engl J Med 1992; 327: 488–90.Google Scholar
7.Zuckerman, JN, Cockcroft, A, Griffiths, P. Hepatitis A vaccination. B M J 1991; 303: 247.CrossRefGoogle Scholar
8.Poole, CJM, Shakespeare, AT. Should sewage workers and carers for people with learning disabilities be vaccinated for hepatitis A? B M J 1993; 306: 1102.CrossRefGoogle ScholarPubMed
9.Jilg, W. Adult use of hepatitis A vaccine in developed countries. Vaccine 1993: 11 (Suppl 1): S6–8.CrossRefGoogle ScholarPubMed
10.Hoffmann, F, Wehrle, G, Berthold, H, Koster, D. Hepatitis A as an occupational hazard. Vaccine 1992; 10 (Suppl 1): S82–4.Google Scholar
11.Tilzey, AJ, Palmer, SJ, Barrow, S et al. , Clinical trial with inactivated hepatitis A vaccine and recommendations for its use. B M J 1992; 304: 1272–6.CrossRefGoogle ScholarPubMed
12. Anonymous. Hepatitis A: a vaccine at last. Lancet 1992; 339: 1198–9.Google Scholar
13.PHLS Working Group. The present state of hepatitis A infection in England and Wales. PHLS Microbiol Dig 1991; 8: 122–6.Google Scholar
14.Banatvala, JE, Tilzey, AJ. Recommendations for use of hepatitis A vaccine. B M J 1992; 304: 1570.CrossRefGoogle Scholar
15.Longson, PJ. Hepatitis A vaccine. B M J 1992; 305: 888.CrossRefGoogle ScholarPubMed
16.Maguire, H. Hepatitis A infection: risk to sewage workers unproved. B M J 1993; 307: 561.Google Scholar
17.Anand, JK. Hepatitis A vaccine for sewage workers. B M J 1992; 305: 477.CrossRefGoogle Scholar
18.Noguchi, A, Hayashi, J, Nakashima, K, Ikematsu, H, Hirata, M, Kashiwagi, S. Decrease of hepatitis A and B virus infections in the populations of Okinawa, Japan. J Infect 1991; 23: 255–62.Google Scholar
19.Kilpatrick, ME, Escamilla, J. Hepatitis A in Peru: the role of children. Am J Epidemiol 1986; 14: 111–13.CrossRefGoogle Scholar
20.Gust, ID, Lehmann, NI, Lucas, CR. Relationship between prevalence of antibody to hepatitis antigen and age: a cohort effect? J Infect Dis 1978; 138: 425–6.Google Scholar
21.Green, MS, Zaaide, Y. Sibship size as a risk factor for hepatitis A infection. Am J Epidemiol 1989; 129: 800–5.CrossRefGoogle ScholarPubMed
22.Ikematsu, H, Kashiwagi, S, Hayashi, J et al. , A seroepidemiological study of hepatitis A virus infections: statistical analysis of two independent cross-sectional surveys in Okinawa, Japan. Am J Epidemiol 1987; 126: 50–4.Google Scholar
23.Briem, H. Declining prevalence of antibodies to hepatitis A virus infection in Iceland. Scand J Infect Dis 1991; 23: 135–8.CrossRefGoogle ScholarPubMed
24.Green, MS, Tsu, S, Lepon, R. Sociodemographic factors and the declining prevalence of anti-hepatitis A antibodies in young adults in Israel: implications for new hepatitis A vaccines. Internat J Epidemiol 1992; 21: 136–41.CrossRefGoogle ScholarPubMed
25.Lim, WL, Yeoh, EK. Hepatitis A vaccination. Lancet 1992; 339: 304.Google Scholar
26. Anonymous. Prevalence of hepatitis A virus infection in Spain. Scand J Infect Dis 1988; 20: 113–14.CrossRefGoogle Scholar
27.Joussemet, M, Bourin, Ph, Lebot, O, Fabre, G, Deloince, R. Evolution of hepatitis A antibodies: prevalence in young French military recruits. Eur J Epidemiol 1992; 8: 289–91.CrossRefGoogle ScholarPubMed
28.Stroffolini, T, De Crescenzo, L, Giammanco, A et al. , Changing patterns of hepatitis A virus infection in children in Palermo, Italy. Eur J Epidemiol 1990; 6: 84–7.CrossRefGoogle ScholarPubMed
29.Hadler, SC, MacFarland, L. Hepatitis in day care centers: epidemiology and prevention. Rev Infect Dis 1985; 8: 548–57.Google Scholar
30.De Filippis, P, Divizia, M, Mele, A, Adamo, B, Pana, A. Detection of hepatitis A virus in the stools of healthy people from endemic areas. Eur J Epidemiol 1987; 3: 172–5.CrossRefGoogle ScholarPubMed
31.Prakazchikov, SA, Balayan, MS. Shifts in the rates and levels and antibody to hepatitis A virus associated with hepatitis A infection in children's communities. Eur J Epidemiol 1987; 3: 370–6.CrossRefGoogle Scholar
32.Rooney, PJ, Coyle, PV. The role of herd immunity in an epidemic cycle of hepatitis A. J Infect 1992; 24: 327–31.Google Scholar
33.Gingrich, GA, Hadler, SC, Elder, HA, Owen, AK. Serological investigation of an outbreak of hepatitis A in a rural day care centre. Am J Epidemiol 1983; 73: 1190–3.Google Scholar
34.Lemon, SM. Type A viral hepatitis. New developments in an old disease. New Engl J Med 1985; 313: 1059–67.CrossRefGoogle Scholar
35.Polakoff, S. Clinical hepatitis A: Laboratory reports years 1980–8. Commun Dis Report 1989; 89/46: 3–6.Google Scholar
36.Timothy, E, Mephan, P. Outbreak of infective hepatitis amongst sewage sludge spreaders. Commun Dis Report 1984; 84/03: 3.Google Scholar
37.World Health Organisation. Weekly epidemiological record 1992; 67: 261–3.Google Scholar