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A poxvirus antigen associated with pathogenicity for rabbits

Published online by Cambridge University Press:  25 March 2010

C. J. M. Rondle  and
K. R. Dumbell
C. J. M. Rondle
Affiliation:
Ladds House, Oxford Road, Sevenoaks, Kent
K. R. Dumbell
Affiliation:
St. Mary's Hospital Medical School, London W2 1PG
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White pock variants of cowpox virus give papular lesions on intradermal inoculation of rabbits, without the necrosis and haemorrhage that are produced by wild type cowpox viruses. Rondle & Dumbell (1962) have shown that white pock variants of cowpox virus fail to produce a specific, precipitating antigen which they called ‘d’ substance. In this paper it is shown that ‘d’ is demonstrable in soluble antigen preparations of rabbitpox virus and of neurovirulent strains of vaccinia virus but not in soluble antigens of variola viruses. Two series of recombinant viruses prepared by Dumbell & Bedson (1964) from variola and cowpox and from variola and rabbitpox viruses were tested for the production of ‘d’ substance. These results were compared with the previously recorded effects of these recombinants when inoculated intradermally in rabbits. It is concluded that functional genes determining the production of ‘d’ and of rabbit skin pathogenicity are closely linked on the pox virus genome, but that there is insufficient evidence to say that the two functions are interdependent.

Type
Research Article
Information
Journal of Hygiene , Volume 89 , Issue 3 , December 1982 , pp. 383 - 388
Copyright
Copyright © Cambridge University Press 1982

References

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