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The Phases of Haemophilus pertussis

Published online by Cambridge University Press:  15 May 2009

P. H. Leslie  and
A. D. Gardner
P. H. Leslie
Affiliation:
(From the Sir William Dunn School of Pathology, Oxford.)
A. D. Gardner
Affiliation:
(From the Sir William Dunn School of Pathology, Oxford.)
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Haemophilus pertussis is a uniform species, without fixed varieties or “types.”

After isolation from the human subject it tends to pass through a series of antigenically distinct phases, of which the first two are toxic to guinea-pigs, whereas the last two are relatively harmless. The former probably correspond to the smooth, the latter to the rough phase of other bacteria.

The phase-changes are, up to a point, reversible.

Experiments on guinea-pigs have produced some evidence that the toxic Phase I is the best and perhaps the only antigen for the production of active immunity in guinea-pigs.

Type
Research Article
Information
Journal of Hygiene , Volume 31 , Issue 3 , July 1931 , pp. 423 - 434
Copyright
Copyright © Cambridge University Press 1931

References

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