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Persistence of rabies antibody 5 years after pre-exposure prophylaxis with human diploid cell antirabies vaccine and antibody response to a single booster dose

Published online by Cambridge University Press:  19 October 2009

F. M. Rodrigues ,
V. B. Mandke ,
M. Roumiantzeff ,
C. V. R. Mohan Rao ,
J. M. Mehta ,
K. M. Pavri  and
C. Poonawalla
F. M. Rodrigues
Affiliation:
National Institute of Virology, 20-A Dr. B. R. Ambedkar Road, Pune 411 001, India;
V. B. Mandke
Affiliation:
National Institute of Virology, 20-A Dr. B. R. Ambedkar Road, Pune 411 001, India;
M. Roumiantzeff
Affiliation:
Institut Merieux, 58 Avenue Leclerc, Lyon, France
C. V. R. Mohan Rao
Affiliation:
National Institute of Virology, 20-A Dr. B. R. Ambedkar Road, Pune 411 001, India;
J. M. Mehta
Affiliation:
Serum Institute of India Research Foundation, Hadapsar, Pune 411 028, India
K. M. Pavri
Affiliation:
National Institute of Virology, 20-A Dr. B. R. Ambedkar Road, Pune 411 001, India;
C. Poonawalla
Affiliation:
Serum Institute of India Research Foundation, Hadapsar, Pune 411 028, India
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In 1978, 22 staff members of the National Institute of Virology, Pune, India, were given two doses of human diploid cell antirabies vaccine (HDCV) for primary pre-exposure prophylactic immunization; the interval between the two doses being approximately 4 weeks. Eighteen of these 22 vaccinees were given a booster dose 1 year later. All 18 vaccinees developed protective levels of antibody; most of them had antibody levels exceeding 10 IU/ml.

In 1984, 5 years after the booster dose, 11 (79·0%) of 14 vaccinees tested still possessed neutralizing antibody levels ranging from 0·5 IU/ml to 10 IU/ml. Fourteen days after the administration of a booster dose, the antibody levels ranged from 10 to ≥ 100 IU/ml for all except one vaccinee (5·2 IU/ml). These findings demonstrate that the majority of vaccinees retained detectable neutralizing antibody after pre-exposure prophylaxis for as long as 5 years and that a single booster dose thereafter evoked a good antibody response.

Type
Research Article
Information
Epidemiology & Infection , Volume 99 , Issue 1 , August 1987 , pp. 91 - 95
Copyright
Copyright © Cambridge University Press 1987

References

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