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Persistence of poliovirus-neutralizing antibodies 2–16 years after immunization with live attenuated vaccine. A seroepidemiologic survey in the mainland of Venice.

Published online by Cambridge University Press:  15 May 2009

R. Trivello
Affiliation:
School of Hygiene and Preventive Medicine, University of Padua, Italy
G. Renzulli
Affiliation:
School of Hygiene and Preventive Medicine, University of Padua, Italy
G. Farisano
Affiliation:
Laboratory of Clinical Chemistry and Immunology, Hospital of Dolo (Venice), Italy
C. Bonello
Affiliation:
Laboratory of Clinical Chemistry and Immunology, Hospital of Dolo (Venice), Italy
M. Moschen
Affiliation:
University of Verona, Italy
V. Gasparini
Affiliation:
School of Hygiene and Preventive Medicine, Trieste, Italy
G. Benussi
Affiliation:
School of Hygiene and Preventive Medicine, Trieste, Italy
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Summary

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A seroepidemiological survey was conducted on subjects who had received a full vaccination course with live attenuated poliovirus 2–16 years before. For strains 1 and 2 prevalence of seropositives and median values dropped gradually during the first 10 years; strain 3 showed a much earlier decline. Environmental displacement of wild poliovirus by the attenuated, less immunogenic strain might eventually induce a ‘gap’, should complacency hamper needed vaccination efforts.

Type
Research Article
Copyright
Copyright © Cambridge University Press 1988

References

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