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Patient and strain characteristics in relation to the outcome of meningococcal disease: a multivariate analysis

Published online by Cambridge University Press:  15 May 2009

R. J. P. M. Scholten ,
H. A. Bijlmer ,
H. A. Valkenburg  and
J. Dankert
R. J. P. M. Scholten
Affiliation:
Institute for Research in Extramural Medicine, Vrije Universiteit, Van der Boechorststraat 7. 1081 BT, Amsterdam, The Netherlands Netherlands Reference Laboratory for Bacterial Meningitis, WHO Collaborating Centre, University of Amsterdam/National Institute for Public Health and Environmental Protection, Amsterdam, The Netherlands
H. A. Bijlmer
Affiliation:
Netherlands Reference Laboratory for Bacterial Meningitis, WHO Collaborating Centre, University of Amsterdam/National Institute for Public Health and Environmental Protection, Amsterdam, The Netherlands
H. A. Valkenburg
Affiliation:
Institute for Research in Extramural Medicine, Vrije Universiteit, Van der Boechorststraat 7. 1081 BT, Amsterdam, The Netherlands
J. Dankert
Affiliation:
Netherlands Reference Laboratory for Bacterial Meningitis, WHO Collaborating Centre, University of Amsterdam/National Institute for Public Health and Environmental Protection, Amsterdam, The Netherlands
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To investigate the joint association of patient and strain characteristics with the outcome of meningococcal disease (MD), data were collected on 563 consecutive cases of MD reported between 1989 and 1990 in The Netherlands. The meningococcal isolates were characterized with regard to their surface characteristics. Sequelae occurred in 8.5% of the patients, and were only associated with the presence of bacteraemia. The case-fatality rate was 7.7%. Infants aged ≤ 5 months and patients in the age-groups of 10–19 years and ≥ 50 years had an increased risk for a fatal outcome compared with children from 6 months to 9 years old (Odds Ratios [ORs]: 5.1, 3.4 and 9.8, respectively). The OR for females versus males was 2.3. The ORs for patients with bacteraemia, or a combination of bacteraemia and meningitis, compared with meningitic patients, were 2.3 and 3.1. Meningococcal strain characteristics did not influence the case-fatality rate substantially. In conclusion, host factors were found to be determinants for a fatal outcome of MD in The Netherlands from 1989 to 1990.

Type
Research Article
Information
Epidemiology & Infection , Volume 112 , Issue 1 , February 1994 , pp. 115 - 124
Copyright
Copyright © Cambridge University Press 1994

References

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