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Outbreak of vertigo in Wyoming: possible role of an enterovirus infection

Published online by Cambridge University Press:  15 May 2009

L. Simonsen ,
A. S. Khan ,
H. E. Gary Jr ,
C. Hanson ,
M.A. Pallansch ,
S. Music ,
R. C. Holman ,
J. A. Stewart ,
D.D. Erdman  and
N. H. Arden
...Show all authors
L. Simonsen
Affiliation:
Division of Viral and Rickettsial Diseases, National Center for Infections Diseases, Mailstop A-32, Centers for Disease Control and Prevention, 1600 Clifton Rd, NE., Atlanta, GA 30333, USA
A. S. Khan
Affiliation:
Division of Viral and Rickettsial Diseases, National Center for Infections Diseases, Mailstop A-32, Centers for Disease Control and Prevention, 1600 Clifton Rd, NE., Atlanta, GA 30333, USA
H. E. Gary Jr
Affiliation:
Division of Viral and Rickettsial Diseases, National Center for Infections Diseases, Mailstop A-32, Centers for Disease Control and Prevention, 1600 Clifton Rd, NE., Atlanta, GA 30333, USA
C. Hanson
Affiliation:
Hot Springs County Hospital, Thermopolis, WY, USA
M.A. Pallansch
Affiliation:
Division of Viral and Rickettsial Diseases, National Center for Infections Diseases, Mailstop A-32, Centers for Disease Control and Prevention, 1600 Clifton Rd, NE., Atlanta, GA 30333, USA
S. Music
Affiliation:
Wyoming State Health Department, Cheyenne, WY, USA
R. C. Holman
Affiliation:
Division of Viral and Rickettsial Diseases, National Center for Infections Diseases, Mailstop A-32, Centers for Disease Control and Prevention, 1600 Clifton Rd, NE., Atlanta, GA 30333, USA
J. A. Stewart
Affiliation:
Division of Viral and Rickettsial Diseases, National Center for Infections Diseases, Mailstop A-32, Centers for Disease Control and Prevention, 1600 Clifton Rd, NE., Atlanta, GA 30333, USA
D.D. Erdman
Affiliation:
Division of Viral and Rickettsial Diseases, National Center for Infections Diseases, Mailstop A-32, Centers for Disease Control and Prevention, 1600 Clifton Rd, NE., Atlanta, GA 30333, USA
N. H. Arden
Affiliation:
Division of Viral and Rickettsial Diseases, National Center for Infections Diseases, Mailstop A-32, Centers for Disease Control and Prevention, 1600 Clifton Rd, NE., Atlanta, GA 30333, USA
I. K. Arenberg
Affiliation:
International Meniere's Disease Research Institute, Englewood, CO, USA
L. B. Schonberger
Affiliation:
Division of Viral and Rickettsial Diseases, National Center for Infections Diseases, Mailstop A-32, Centers for Disease Control and Prevention, 1600 Clifton Rd, NE., Atlanta, GA 30333, USA
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Summary

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An epidemiologic investigation was conducted to characterize and evaluate the possibility of a viral aetiology of an outbreak of acute vertigo in Hot Springs Country, Wyoming, during autumn 1992. Case-finding identified Hot Springs County residents who sought medical attention for new onset vertigo during 1 August, 1992–31 January 1993. Thirty-five case-patients and 61 matched controls were interviewed and serum specimens were obtained during January 1993. Case-patients were more likely than controls to report symptoms (e.g. fatigue, sore throat, fever, diarrhoea) of antecedent acute illness. Case-patients did not have a significantly greater prevalence or mean titre of IgG antibodies to respiratory syncytial virus, parainfluenza viruses, Epstein–Barr virus, and cytomegalovirus than controls. Serologic evidence of recent enterovirus infection (IgM antibodies) was found for 74% of case-patients compared with 54% of controls (P < 0·05), suggesting a possible association between vertigo and enterovirus infection. Future studies are needed to define the role of enteroviruses in inner-ear diseases.

Type
Research Article
Information
Epidemiology & Infection , Volume 117 , Issue 1 , August 1996 , pp. 149 - 157
Copyright
Copyright © Cambridge University Press 1996

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