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Oral dose and faecal concentration of antibiotics during antibiotic decontamination in mice and in a patient

Published online by Cambridge University Press:  15 May 2009

D. van der Waaij ,
J.M. Berghuis-de Vries  and
C. Korthals Altes
D. van der Waaij
Affiliation:
Radiobiological Institute TNO, Rijswijk (Z.H.)
J.M. Berghuis-de Vries
Affiliation:
Radiobiological Institute TNO, Rijswijk (Z.H.)
C. Korthals Altes
Affiliation:
Sophia Children's Hospital, Rotterdam, The Netherlands
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Summary

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In both mice and one patient, a similar correlation was found between the oral dose of a ‘nonabsorbable’;aminoglycoside antibiotic selected for antibiotic decontamination of the digestive tract and the resultant faecal concentration. In mice, absorption of the orally-given antibiotics could only be demonstrated in animals treated with extremely high doses of 1440 mg. per kg. body weight per day. Evidence of absorption of gentamycin was found to occur in a patient after doses as low as 70 mg. per kg. per day.

Type
Research Article
Information
Journal of Hygiene , Volume 73 , Issue 2 , October 1974 , pp. 197 - 203
Copyright
Copyright © Cambridge University Press 1974

References

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