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Ontogenesis of the formation of secretory antibodies to respiratory syncytial (RS) virus

Published online by Cambridge University Press:  15 May 2009

N. P Leschinskaya ,
E. E Pokrovskaya ,
E. A Kantorovitch ,
S.K Grigorjeva  and
YA. S Shvartsman
N. P Leschinskaya
Affiliation:
All-Union Research Institute for Influenza, USSR Ministry of Health, Leningrad
E. E Pokrovskaya
Affiliation:
All-Union Research Institute for Influenza, USSR Ministry of Health, Leningrad
E. A Kantorovitch
Affiliation:
All-Union Research Institute for Influenza, USSR Ministry of Health, Leningrad
S.K Grigorjeva
Affiliation:
All-Union Research Institute for Influenza, USSR Ministry of Health, Leningrad
YA. S Shvartsman
Affiliation:
All-Union Research Institute for Influenza, USSR Ministry of Health, Leningrad
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Summary

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Examination of sera from 184 children aged between 0 and 12 years and 161 adults revealed a close correlation between age and the level of humoral anti-RS virus immunity. Secretory IgG antibodies were found in children in their first months of life. Evidence for their release into secretions from the serum was obtained. This might explain the positive correlation between serum antibody levels in women recently confined with the morbidity due to RS virus in children during their first months of life. Secretory IgA antibodies were found from 4 months untill old age. The secretions of children and adults contained virus-neutralizing activity which was non-immunoglobulin in nature, as well as antibodies. However, in contrast to secretory antibody this material did not prevent development of severe RS virus infections.

Type
Research Article
Information
Epidemiology & Infection , Volume 101 , Issue 3 , December 1988 , pp. 565 - 575
Copyright
Copyright © Cambridge University Press 1988

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