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On the mechanism of silica toxicity

Published online by Cambridge University Press:  15 May 2009

Dinah M. James  and
J. Marks
Dinah M. James
Affiliation:
Department of Pharmacology, Welsh National School of Medicine
J. Marks
Affiliation:
Central Tuberculosis Laboratory, Cardiff
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Silicic acid in its polymerized form is toxic to leucocytes in tissue culture and depresses leucocyte respiration, effects which appear to be paralleled by its inhibition of the cytochrome oxidase enzyme system. There is evidence that silicic acid acts on this system by combining with and inactivating cytochrome c and it is suggested that its effect in vivo may have a similar basis. The inhibitory effect of silicic acid on the two other respiratory enzyme systems studied is considerably less intense and probably non-specific.

Type
Research Article
Information
Journal of Hygiene , Volume 54 , Issue 3 , September 1956 , pp. 342 - 350
Copyright
Copyright © Cambridge University Press 1956

References

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